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SMU Guildhall and cancer researchers level up to tap human intuition of video gamers in quest to beat cancer

Massive computational power of online “Minecraft” gaming community bests supercomputers

Video gamers have the power to beat cancer, according to cancer researchers and video game developers at Southern Methodist University, Dallas.

SMU researchers and game developers are partnering with the world’s vast network of gamers in hopes of discovering a new cancer-fighting drug.

Biochemistry professors Pia Vogel and John Wise in the SMU Department of Biological Sciences, and Corey Clark, deputy director of research at SMU Guildhall, are leading the SMU assault on cancer in partnership with fans of the popular best-selling video game “Minecraft.”

Vogel and Wise expect deep inroads in their quest to narrow the search for chemical compounds that improve the effectiveness of chemotherapy drugs.

“Crowdsourcing as well as computational power may help us narrow down our search and give us better chances at selecting a drug that will be successful,” said Vogel. “And gamers can take pride in knowing they’ve helped find answers to an important medical problem.”

Up to now, Wise and Vogel have tapped the high performance computing power of SMU’s Maneframe, one of the most powerful academic supercomputers in the nation. With ManeFrame, Wise and Vogel have sorted through millions of compounds that have the potential to work. Now, the biochemists say, it’s time to take that research to the next level — crowdsourced computing.

A network of gamers can crunch massive amounts of data during routine gameplay by pairing two powerful weapons: the best of human intuition combined with the massive computing power of networked gaming machine processors.

Taking their research to the gaming community will more than double the amount of machine processing power attacking their research problem.

“With the distributed computing of the actual game clients, we can theoretically have much more computing power than even the supercomputer here at SMU,” said Clark, also adjunct research associate professor in the Department of Biological Sciences. SMU Guildhall in March was named No. 1 among the Top 25 Top Graduate Schools for Video Game Design by The Princeton Review.

“If we take a small percentage of the computing power from 25,000 gamers playing our mod we can match ManeFrame’s 120 teraflops of processing power,” Clark said. “Integrating with the ‘Minecraft’ community should allow us to double the computing power of that supercomputer.”

Even more importantly, the gaming community adds another important component — human intuition.

Wise believes there’s a lot of brainpower eager to be tapped in the gaming community. And human brains, when tackling a problem or faced with a challenge, can make creative and intuitive leaps that machines can’t.

“What if we learn things that we never would have learned any other way? And even if it doesn’t work it’s still a good idea and the kids will still get their endorphin kicks playing the game,” Wise said. “It also raises awareness of the research. Gamers will be saying ‘Mom don’t tell me to go to bed, I’m doing scientific research.”

The Vogel and Wise research labs are part of the Center for Drug Discovery, Design and Delivery (CD4) in SMU’s Dedman College. The center’s mission is a novel multi-disciplinary focus for scientific research targeting medically important problems in human health. Their research is funded in part by the National Institutes of Health.

The research question in play
Vogel and Wise have narrowed a group of compounds that show promise for alleviating the problem of chemotherapy failure after repeated use. Each one of those compounds has 50 to 100 — or even more — characteristics that contribute to their efficacy.

“Corey’s contribution will hopefully tell us which dozen perhaps of these 100 characteristics are the important ones,” Vogel said. “Right now of those 100 characteristics, we don’t know which ones are good ones. We want to see if there’s a way with what we learn from Corey’s gaming system to then apply what we learn to millions of other compounds to separate the wheat from the chaff.”

James McCormick — a fifth year Ph.D. student in cellular molecular biology who earned his doctoral degree this spring and is a researcher with the Center for Drug Discovery, Design and Delivery — produced the data set for Clark and Guildhall.

Lauren Ammerman, a first-year Ph.D. student in cellular and molecular biology and also working in the Center for Drug Discovery, Design and Delivery, is taking up the computational part of the project.

Machines can learn from human problem solving
Crowdsourcing video gamers to solve real scientific problems is a growing practice.

Machine learning and algorithms by themselves don’t always find the best solution, Clark said. There are already examples of researchers who for years sought answers with machine learning, then switched to actual human gamers.

Gamers take unstructured data and attack it with human problem-solving skills to quickly find an answer.

“So we’re combining both,” Clark said. “We’re going to have both computers and humans trying to find relationships and clustering the data. Each of those human decisions will also be supplied as training input into a deep neural network that is learning the ‘human heuristic’ — the technique and processes humans are using to make their decisions.”

Gamers already have proven they can solve research problems that have stymied scientists, says Vogel. She cites the video game “Foldit” created by the University of Washington specifically to unlock the structure of an AIDS-related enzyme.

Some other Games With A Purpose, as they’re called, have produced similar results. Humans outperform computers when it comes to tasks in the computational process that are particularly suited to the human intellect.

“With ‘Foldit,’ researchers worked on a problem for 15 years using machine learning techniques and were unable to find a solution,” Clark said. “Once they created the game, 57,000 players found a solution in three weeks.”

Modifying the “Minecraft” game and embedding research data inside
Gamers will access the research problem using the version of “Minecraft” they purchased, then install a “mod” or “plugin” — gamer jargon for modifying game code to expand a game’s possibilities — that incorporates SMUs research problem and was developed in accordance with “Minecraft” terms of service. Players will be fully aware of their role in the research, including ultimately leaderboards that show where players rank toward analyzing the data set in the research problem.

SMU is partnering with leaders in the large “Minecraft” modding community to develop a functioning mod by the end of 2017. The game will be heavily tested before release to the public the second quarter of 2018, Clark said.

The SMU “Minecraft” mod will incorporate a data processing and distributed computing platform from game technology company Balanced Media Technology (BMT), McKinney, Texas. BMT’s HEWMEN software platform executes machine-learning algorithms coupled with human guided interactions. It will integrate Wise and Vogel’s research directly into the SMU “Minecraft” mod.

SMU Guildhall will provide the interface enabling modders to develop their own custom game mechanic that visualizes and interacts with the research problem data within the “Minecraft” game environment. Guildhall research is funded in part by Balanced Media Technology.

“We expect to have over 25,000 people continuously online during our testing period,” Clark said. “That should probably double the computing power of the supercomputer here.”

That many players and that much computing power is a massive resource attacking the research problem, Wise said.

“The SMU computational system has 8,000 computer cores. Even if I had all of ManeFrame to myself, that’s still less computing and brainpower than the gaming community,” he said. “Here we’ve got more than 25,000 different brains at once. So even if 24,000 don’t find an answer, there are maybe 1,000 geniuses playing ‘Minecraft’ that may find a solution. This is the most creative thing I’ve heard in a long time.” — Margaret Allen, SMU

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NPR: A Tiny Spot In Mouse Brains May Explain How Breathing Calms The Mind

SMU psychology professor Alicia Merit was interviewed by NPR as an expert outside source on a new study about calming the mind.

Public radio network NPR interviewed SMU clinical psychologist Alicia Meuret for her expertise on breathing as it relates to fear and anxiety.

The NPR article, “A Tiny Spot In Mouse Brains May Explain How Breathing Calms The Mind,” published March 30, 2017.

Meuret is director of the Anxiety and Depression Research Center at SMU, with expertise in discussing the differences between fear and anxiety and when each is helpful and adaptive and when they are harmful and interfere with our lives.

An associate professor in the Clinical Psychology Division of the SMU Department of Psychology, Meuret received her Ph.D. in Clinical Psychology from the University of Hamburg based on her doctoral work conducted at the Department of Psychiatry and Behavioral Sciences at Stanford University. She completed postdoctoral fellowships at the Center for Anxiety and Related Disorders at Boston University and the Affective Neuroscience Laboratory in the Department of Psychology at Harvard University.

Her research program focuses on novel treatment approaches for anxiety and mood disorders, biomarkers in anxiety disorders and chronic disease, fear extinction mechanisms of exposure therapy, and mediators and moderators in individuals with affective dysregulations, including non-suicidal self-injury.

The article “A Tiny Spot In Mouse Brains May Explain How Breathing Calms The Mind,” cites new findings from Meuret’s research, which found patients undergoing exposure therapy for anxiety fared better when sessions were held in the morning when levels of the helpful natural hormone cortisone are higher in the brain.

Read the full story.

EXCERPT:

By Jessica Boddy
NPR
Take a deep breath in through your nose, and slowly let it out through your mouth. Do you feel calmer?

Controlled breathing like this can combat anxiety, panic attacks and depression. It’s one reason so many people experience tranquility after meditation or a pranayama yoga class. How exactly the brain associates slow breathing with calmness and quick breathing with nervousness, though, has been a mystery. Now, researchers say they’ve found the link, at least in mice.

The key is a smattering of about 175 neurons in a part of the brain the researchers call the breathing pacemaker, which is a cluster of nearly 3,000 neurons that sit in the brainstem and control autonomic breathing. Through their research is in mice, the researchers found that those 175 neurons are the communication highway between the breathing pacemaker and the part of the brain responsible for attention, arousal and panic. So breathing rate could directly affect feeling calm or anxious, and vice versa.

If that mouse pathway works the same way in humans, it would explain why we get so chilled out after slowing down our breathing. […]

[…] Alicia Meuret, an associate professor of psychology at Southern Methodist University who also wasn’t involved in the study, wasn’t sure if what the authors described as calm mouse behavior could be described as such. “It’s hard to determine what calm behavior is [in mice],” Meuret says. “We can see their behavior, but we don’t know what effect the loss of neurons has on their emotions.”

Banzett echoed that concern, noting the authors inferred emotion because “they equate the increase in grooming behavior with the emotional state of calmness.”

Read the full story.

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Culture, Society & Family Health & Medicine Learning & Education Mind & Brain Researcher news SMU In The News

KERA News: Teens In Low-Income Families Get HPV Vaccine If Parents Persuade Themselves Of Benefits

In the first study of its kind, self-persuasion software on an iPad motivated low-income parents to want to protect their teens against the cancer-causing Human Papillomavirus.

Journalist Justin Martin with KERA public radio news covered the research of SMU psychology professor Austin S. Baldwin, a principal investigator on the research.

KERA’s article, “Teens In Low-Income Families Get HPV Vaccine If Parents Persuade Themselves Of Benefits,” aired April 12, 2017.

The SMU study found that low-income parents will decide to have their teens vaccinated against the sexually transmitted cancer-causing virus if the parents persuade themselves of the protective benefits.

The study’s subjects — almost all moms — were taking their teens and pre-teens to a safety-net pediatric clinic for medical care. It’s the first to look at changing parents’ behavior through self-persuasion using English- and Spanish-language materials.

A very common virus, HPV infects nearly one in four people in the United States, including teens, according to the Centers for Disease Control. HPV infection can cause cervical, vaginal and vulvar cancers in females; penile cancer in males; and anal cancer, back of the throat cancer and genital warts in both genders, the CDC says.

The CDC recommends a series of two shots of the vaccine for 11- to 14-year-olds to build effectiveness in advance of sexual activity. For 15- to 26-year-olds, they are advised to get three doses over the course of eight months, says the CDC.

Currently, about 60% of adolescent girls and 40% of adolescent boys get the first dose of the HPV vaccine. After that, about 20% of each group fail to follow through with the second dose, Baldwin said.

Listen to the KERA radio interview with Justin Martin.

EXCERPT From KERA News:

Guilt, social pressure and even a doctor’s recommendation aren’t enough to motivate low-income families to vaccinate their teenagers for Human Papillomavirus (HPV), according to research from Southern Methodist University.

But a follow-up study from SMU finds that if parents persuade themselves of the benefits of the vaccinations, more teenagers in low-income families receive protection from the sexually transmitted, cancer-causing virus.

Austin Baldwin, a professor of psychology at SMU, led the research.

What the study tells us about poverty: HPV is a sexually transmitted virus that is the primary cause of a variety of cancers. There’s been a vaccine developed in the last 10 years, 12 years that’s now approved. At times, those who are underinsured or uninsured don’t have this same level of access to it. Both here locally as well as nationally [among] folks who are poor, who are uninsured, we see clear disparities across a variety of health outcomes including cancer, including cervical cancer. The HPV vaccine is potentially a very effective means to address some of those health disparities.

How the study was conducted: We recruited parents of adolescents who get their pediatric care at Parkland clinic, and they participated in an iPad app that we developed. It provides them with some basic information about HPV and about the vaccine. It then prompts them with a number of questions to think about why getting the vaccine may be important, and then it prompts them to generate their own reasons for why they would get the vaccine. Most of the parents who had not previously given thought to or were undecided about the vaccine reported that they had decided to get their adolescent vaccinated.

Listen to the KERA radio interview with Justin Martin.

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Relentless gene hunter, NIH Director Francis Collins, to speak at SMU Commencement May 20

Collins is best known for leading the Human Genome Project, the world’s largest collaborative biological project and one of the most significant scientific undertakings in modern history.

Francis S. Collins, M.D., Ph.D., the director of the National Institutes of Health, who may be best known for leading the Human Genome Project, will be the featured speaker during SMU’s 102nd all-University Commencement ceremony at 9 a.m. Saturday, May 20, in Moody Coliseum.

Collins — whose own personal research efforts led to the isolation of the genes responsible for cystic fibrosis, neurofibromatosis, Huntington’s disease and Hutchinson-Gilford progeria syndrome — will receive the Doctor of Science degree, honoris causa, from SMU during the ceremony. The entire event, including Collins’ address, will be live streamed at smu.edu/live.

“We are honored to have a pioneering scientist and national leader of Dr. Collins’ stature as featured speaker at Commencement,” said SMU President R. Gerald Turner. “His life is testament to a strong, unwavering commitment to the search for scientific knowledge paired with deep religious faith. He has much to share with us.”

As NIH director, Collins oversees the work of the largest institutional supporter of biomedical research in the world, spanning the spectrum from basic to clinical research. He was appointed by President Obama in 2009 and was asked to remain in the position by President Trump in January 2017. As director, he has helped launch major research initiatives to advance the use of precision medicine for more tailored healthcare, increase our understanding of the neural networks of the brain to improve treatments for brain diseases, and identify areas of cancer research that are most ripe for acceleration to improve cancer prevention and treatment.

While director of NIH’s National Human Genome Research Institute, he oversaw the Human Genome Project, a 13-year international effort to map and sequence the 3 billion letters in human DNA. HGP scientists finished the sequence in April 2003, coinciding with the 50th anniversary of James Watson and Francis Crick’s seminal publication describing the double-helix structure of DNA.

It remains the world’s largest collaborative biological project and one of the most significant scientific undertakings in modern history.

As an innovative evolutionary geneticist and a devout Christian, Collins also has gained fame for his writings on the integration of logic and belief. His first book, The Language of God: A Scientist Presents Evidence for Belief, became a New York Times bestseller in 2006. Since then, he has written The Language of Life: DNA and the Revolution in Personalized Medicine (2011) and edited a selection of writings, Belief: Readings on the Reason for Faith (2010).

Born in Staunton, Va., and raised on a small family farm in the Shenandoah Valley, Collins was home schooled until the sixth grade and attended Robert E. Lee High School in his hometown. He earned his Bachelor of Science degree in chemistry from the University of Virginia in 1970.

In 1974, Collins received his Ph.D. degree in physical chemistry from Yale University, where a course in molecular biology triggered a major change in career direction. He enrolled in medical school at the University of North Carolina-Chapel Hill, where he earned his M.D. degree in 1977. From 1978 to 1981, Collins completed a residency and chief residency in internal medicine at North Carolina Memorial Hospital. He then returned to Yale as a Fellow in Human Genetics at the university’s medical school from 1981 to 1984.

Dr. Collins joined the University of Michigan in 1984 as a Howard Hughes Medical Institute investigator, a position that would eventually lead to a Professorship of Internal Medicine and Human Genetics. Collins heightened his reputation as a relentless gene hunter with an approach he named “positional cloning,” which has developed into a powerful component of modern molecular genetics.

In contrast to previous methods for finding genes, positional cloning enabled scientists to identify disease genes without knowing the functional abnormality underlying the disease in advance. Collins’ team, together with collaborators, applied the new approach in 1989 in their successful quest for the long-sought gene responsible for cystic fibrosis. Other major discoveries soon followed, including isolation of the genes for Huntington’s disease, neurofibromatosis, multiple endocrine neoplasia type 1, the M4 type of adult acute leukemia, and Hutchinson-Gilford progeria syndrome.

In 1993, Collins joined NIH to become director of the National Center for Human Genome Research, which became NHGRI in 1997. As director, he oversaw the International Human Genome Sequencing Consortium and many other aspects of what he has called “an adventure that beats going to the moon or splitting the atom.”

An elected member of the Institute of Medicine and the National Academy of Sciences, Dr. Collins was awarded the Presidential Medal of Freedom in November 2007 from President George W. Bush. He received the National Medal of Science in 2009.

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Male versus female college students react differently to helicopter parenting, study finds

Helicopter parenting reduces the well-being of young women, while the failure to foster independence harms the well-being of young men but not young women.

Male and female college students react differently to misguided parenting, according to a new study that looked at the impact of helicopter parenting and fostering independence.

Measuring both helicopter parenting as well as autonomy support — fostering independence — was important for the researchers to study, said family dynamics expert Chrystyna Kouros, an assistant professor of psychology at Southern Methodist University, Dallas, and an author on the study.

“Just because mom and dad aren’t helicopter parents, doesn’t necessarily mean they are supporting their young adult in making his or her own choices,” Kouros said. “The parent may be uninvolved, so we also wanted to know if parents are actually encouraging their student to be independent and make their own choices.”

The researchers found that young women are negatively affected by helicopter parenting, while young men suffer when parents don’t encourage independence.

“The sex difference was surprising,” said Kouros, an expert in adolescent depression. “In Western culture in particular, boys are socialized more to be independent, assertive and take charge, while girls are more socialized toward relationships, caring for others, and being expressive and compliant. Our findings showed that a lack of autonomy support — failure to encourage independence — was more problematic for males, but didn’t affect the well-being of females. Conversely, helicopter parenting — parents who are overinvolved — proved problematic for girls, but not boys.”

The study is unique in measuring the well-being of college students, said Kouros, director of the Family Health and Development Lab at SMU. The tendency in research on parenting has been to focus on the mental health of younger children.

“When researchers do focus on college students they tend to ask about academic performance, and whether students are engaged in school. But there haven’t been as many studies that look at mental health or well-being in relation to helicopter parenting,” she said.

Unlike children subjected to psychological control, in which parents try to instill guilt in their child, children of helicopter parents report a very close bond with their parents. Helicopter parents “hover” out of concern for their child, not from malicious intent, she said.

What helicopter parents don’t realize is that despite their good intentions to help their child, it actually does harm, said Naomi Ekas, a co-author on the study and assistant professor of psychology at Texas Christian University, Fort Worth.

“They’re not allowing their child to become independent or learn problem-solving on their own, nor to test out and develop effective coping strategies,” Ekas said.

Young men that reported more autonomy support, measured stronger well-being in the form of less social anxiety and fewer depressive symptoms.

For young women, helicopter parenting predicted lower psychological well-being. They were less optimistic, felt less satisfaction with accomplishments, and were not looking forward to things with enjoyment, nor feeling hopeful. In contrast, lacking autonomy support wasn’t related to negative outcomes in females.

“The take-away is we have to adjust our parenting as our kids get older,” said Kouros. “Being involved with our child is really important. But we have to adapt how we are involved as they are growing up, particularly going off to college.”

The findings were reported in the article “Helicopter Parenting, Autonomy Support, and College Students’ Mental Health and Well-being: The Moderating Role of Sex and Ethnicity,” in the Journal of Child and Family Studies.

Other co-authors were: Romilyn Kiriaki and Megan Sunderland, SMU Department of Psychology, and Megan M. Pruitt, Texas Christian University. The study was funded by the Hogg Foundation for Mental Health at the University of Texas at Austin.

Parental involvement can go too far
Research on child development has consistently found that children are more successful when they have parental involvement and support.

Now, however, research is finding that parental involvement can go too far. Call it over-parenting, over-controlling parenting or helicopter parenting, but the characteristics are the same: parents offer their child a lot of warmth and support, but in combination with high levels of control and low levels of autonomy and independence.

For example a parent may dispute their college student’s low grade with a professor or negotiate their young adult’s job offer and salary.

Previous research in the field has linked helicopter parenting to a student’s poor academic achievement, lower self-esteem and life satisfaction, poor peer relationships, and greater interpersonal dependency.

“With helicopter parenting you’re impeding children from meeting the developmental goals of being independent and autonomous,” Kouros said. “That lowers their confidence in being able to solve problems on their own. They lose the opportunity to learn how to deal with stressors. Someone who’s used to figuring out daily hassles, however, learns strategies, gets practice and knows problems aren’t the end of the world.”

In contrast, research in the field links positive outcomes when parents support autonomy and independence by encouraging their young adults to make decisions and solve problems. Autonomy support is related to higher self-esteem and less depression.

Minimal research into sex differences of young adults
For the current study, the researchers wanted to see if helicopter parenting and low autonomy support equally affected male and female students.

Researching potential differences was especially important, the researchers concluded, since studies have found that females are twice as prone as males to develop depression and anxiety.

Very little research of sex differences has been conducted in emerging adulthood in relation to parenting. What limited research there is suggests that over-controlling or lax parenting increases the risk for maladjustment, particularly for young women.

The researchers surveyed 118 undergraduate students recruited from two mid-sized private universities in the southwest United States. The majority of students were female, between 18 and 25 years old, primarily white and Hispanic and living on campus.

Students completed widely accepted measures of helicopter parenting and autonomy support. The questionnaires asked students to rank their agreements or disagreement on a scale for items such as “If I were to receive a low grade that I felt was unfair, my parents would call the professor,” or “My parents encourage me to make my own decisions and take responsibility for the choices I make.”

To assess mental health and well-being, the students completed an accepted inventory for depression and anxiety symptoms that asked questions about their feelings the past two weeks. Examples include, “I felt depressed,” “I felt self-conscious knowing that others were watching me,” and “I felt hopeful about the future.”

The study complements a growing body of research about the harmful effects of helicopter parenting for adult children. It also adds to research indicating females are more vulnerable to the negative effects than males.

“You should love and care for your child, but the way you show it and manifest it has to be developmentally appropriate. Your parenting has to follow where your child is developmentally,” Kouros said. “Being over-involved while your child is in college, that may not be appropriate anymore. That doesn’t mean you disengage. So if a college student wants to call their parent and talk through an issue and problem solve, I think that’s appropriate. But it’s their problem and they should be able to confidently handle it on their own.” — Margaret Allen