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Culture, Society & Family Learning & Education Student researchers

Gender gap at top U.S. universities for women scientists

Lincoln2.jpgAccording to the National Research Council in 2006, women earned 44.7 percent of the doctorates awarded in the biological sciences between 1993 and 2004. Yet women comprised only 30.2 percent of the assistant professors at the top 50 U.S. universities.

In physics, the gap is far wider. Anne Lincoln, assistant professor of sociology in SMU’s Dedman College, is researching the reasons for the gender disparities.

In September Lincoln received a three-year grant from the National Science Foundation’s Research on Gender in Science and Engineering program.

Lincoln will examine women’s and men’s reasons for pursuing academic science careers as well as their perceptions about women’s contributions to academic science.

Lincoln and a team of four sociology undergraduate students are nearing the completion of the sampling database. They have been preparing a list of all faculty and graduates students at top-20 biology and physics graduate departments in the United States. From that they will randomly select 2,500 to participate in an Internet-based survey.

ecklund.jpgA subsample of about 150 respondents will later be selected for more in-depth interviews, which will take place in 2009.

“In 2010, we will be wrapping up the study and mostly running analyses on the data,” she says.

Lincoln’s co-investigator is Elaine Howard Ecklund of Rice University.

In addition to expanding recent scholarly findings related to the role perceptions have in the decision to pursue a career in academic science, Lincoln’s research is expected to provide the “necessary research underpinnings to build university policies and practices that encourage women’s interest in science majors and careers.”

Related links:
Anne Lincoln
Elaine Howard Ecklund
SMU Department of Sociology
National Research Council
Dedman College of Humanities and Sciences

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Energy & Matter Health & Medicine Plants & Animals Student researchers

Aids, cancer targeted by biology researchers

In his third-floor laboratory in Dedman Life Sciences Building, biologist Robert Harrod and his team are zeroing in on a new way to inhibit the virus that causes AIDS. They already have shown that their approach, which involves the rare genetic disorder Werner syndrome, works when the disorder’s enzyme defect is introduced into cells.

Now they are trying to find practical ways to use this pathway to inhibit the AIDS virus. The beauty of this approach is that the AIDS virus will not be able to mutate in a way that can defeat this treatment, says Harrod, associate professor in the Biological Sciences Department of Dedman College.

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Down the hall from Harrod’s lab, Assistant Professor of Biological Sciences Jim Waddle is preparing to file for a patent on a tiny “worm” that is expected to be highly useful in drug-testing, producing results far more quickly than tests run on larger lab creatures.

Meanwhile, their colleagues, Associate Professor Pia Vogel and her husband, John Wise, a lecturer in the Biological Sciences Department, are conducting work that may have implications for cancer treatment.

In university laboratories throughout the world, enormous strides have been made in biology research in recent years, including the mapping of the human genome. With young faculty members like Harrod, Waddle and Vogel working on cutting-edge conundrums, and a recent $3.6 million gift to Biological Sciences, SMU’s department is poised to play a high-profile role in biology advances in coming years, says William Orr, chair and professor of biological sciences.

The gift from philanthropist and SMU Board of Trustees member Caren Prothro and the Perkins-Prothro Foundation includes $2 million for an endowed chair, $1 million for an endowed research fund, $500,000 for a graduate fellowship fund and $100,000 for an undergraduate scholarship fund.

The endowment will enable the University to attract a biologist with a national reputation in research to join a faculty that is strong in cellular and molecular biology and biochemistry and is doing research that could have practical applications in medicine, Orr says.

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For example, Vogel and Wise are looking for a way to improve the long-term efficacy of chemotherapy treatments. Wise uses a nautical metaphor to explain their work: “Picture a cancer cell as a ship on a sea and the chemotherapy being dumped into the ship, there’s a mechanism like a sump pump that will dump that chemical back overboard,” he says.

That cellular “sump pump” is important to normal cell health because it keeps toxins out.

“Of course, with cancer cells that are targeted for destruction by chemotherapeutics, you’d like to be able to turn off that mechanism,” Wise adds.

John Wise

Vogel explains that many cancer cells respond to treatment by pumping out more and more of the toxins as time goes on, so that a cancer treatment that works well initially might not work as well in later stages.

“Switching chemotherapy drugs doesn’t help because the cancer cells just pump out everything, resulting in multi-drug resistance,” she says.

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Using Electron Spin Resonance Spectroscopy, a biophysical technique that obtains structural information about the cellular pump, Vogel’s research group is trying to find a way to shut off the ATP energy usage by this cellular sump pump.

“If you can knock out the pump, you can sink the cancer ship,” she says.

Harrod, who studies retroviruses that infect humans and who is focusing on transcriptional gene regulation, is working on a mechanism that might sidestep a more specific type of multidrug resistance — of the virus that causes AIDS to the conventional HAART (highly active antiretroviral treatment) drug regimen.

Pia Vogel

His approach is related to a rare genetic disorder called Werner syndrome, which causes premature aging in those who have the disease. Researchers have noted that individuals who are carriers for Werner syndrome do not develop AIDS. Harrod hypothesized that the enzyme involved in Werner syndrome is necessary for transcription of the retrovirus.

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Using cells that had the Werner syndrome defect inserted into them, his lab was able to confirm this link, and last year he and co-researchers published the findings in “The Journal of Biological Chemistry.” Now his group is looking for molecules that might be used to block this transcription-necessary enzyme. Included among the researchers cited in the journal article were several biological sciences students. Both graduate and undergraduate students assisted Harrod in his lab work on retroviral transcription.

Ask Assistant Professor Jim Waddle about the contributions made by students, and he’ll talk about the weird “worm” discovered by one of his graduate students. Waddle, whose Ph.D. work was in molecular genetics, has been studying the nematode Caenorhabditis elegans as a model for food absorption in the human gut.

Fingerlike projections called microvilli, which are necessary for the absorption of nutrients, line the human gut; nematodes have microvilli on every gut cell.

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As part of their research, Waddle’s lab doused the nematodes in mutation-causing chemicals and examined them via a fluorescent protein.

Ph.D. candidate Christina Paulson looked at 20,000 nematodes in this manner and came up with one that had a nematode version of diverticulosis, with outpouchings all along the gut.

Disappointingly, the mutated worm turned out to be normal in terms of lifespan, reproduction and absorption of nutrients. But, Waddle says, “we threw our heads together and thought about conditions the nematode might encounter in the wild” versus the laboratory setting. He wondered if the worm might have trouble eliminating toxins. It did.

Jim Waddle

Normal nematodes eliminate toxins too quickly for the worms to be useful in drug testing, but toxins stay in the weird worms long enough to have an effect on them. And that means the millimeter-long creature likely will be highly useful in drug-testing situations, because a nematode’s life cycle is so much shorter than that of the larger animals, such as mice, that generally are used to test drugs.

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The student who identified the worm is one of 18 graduate students in the Department of Biological Sciences. Nine are working on Master’s degrees, nine on Ph.Ds. With 126 undergraduates, the department enrolls the largest segment of undergraduate majors in the natural sciences at SMU. Undergraduate students who intend to go into biological research can apply for the BRITE (Biomedical Researchers in Training Experience) program, a collaboration between SMU and the University of Texas Southwestern Medical Center that leads to acceptance into a UT Southwestern Ph.D. program.

Orr believes the department is poised for a leap forward in size and stature. Administrative support to boost research has come from Provost Paul Ludden, whose background is in biochemistry. Current research projects are supported by $4.3 million from agencies that include the National Institutes of Health and the National Science Foundation.
Christina Paulson

Orr’s dream for the department is to double the current tenured and tenure-track faculty to 18 members. Of the nine, seven conduct ongoing research projects, five of which are funded by federal agencies. The department will add an assistant professor in spring 2009. Later that year, a national search will be conducted to fill the new Distinguished Chair of Biological Sciences.

william.jpgAlthough the department is small, a synergy has developed from building a faculty that is focused on cellular and molecular biochemistry, Orr says.

Researchers can work together on projects, brainstorming ideas for new areas of investigation. More grants can be applied for, which means more grants awarded.

“We have a strong group that is focused on certain areas. By adding new faculty we will be able to boost the overall stature of the department,” Orr says. “If we increase the academic stature and the amount of research, we can provide more opportunities for graduate students and for undergraduates. It all works together.” — Cathy Frisinger

William Orr

Related links:
Robert Harrod
Jim Waddle
Pia Vogel
John Wise
William Orr
Biological Sciences Department
Dedman College of Humanities and Sciences

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Researcher news Student researchers

Faculty mentor student researchers in both lab, field

Through their research, SMU professors not only bring new information and insights to their classrooms, but also serve as role models and collaborators to students who conduct research in their laboratories across campus.

Maintaining a strong research program is significant for a number of reasons, says James Quick, associate vice president for research and dean of graduate studies.

“Research programs serve as a recruiting tool that helps a university attract the best students,” Quick says. “Research also increases the diversity of ideas on campus and creates opportunities for different departments to work together on interdisciplinary projects.”

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In support of SMU’s commitment to research at both faculty and student levels, which is part of the University’s long-term strategic plan, Quick is seeking to more than triple SMU’s annual research spending to $50 million.

He emphasizes that the top 50 universities in the country, as ranked by “U.S. News & World Report,” each conduct more than $50 million a year in research.

“The great universities of the 21st century will spend significant amounts of funds on research,” Quick says. From anthropology to engineering to religious studies, SMU undergraduate and graduate students and their faculty mentors are discovering new knowledge and playing an important role in higher education through their contributions to research.

Lessons From Bolivia
In summer 2007, SMU Seniors Erin Eidenshink and Katie Josephson spent eight weeks in Cochabamba, Bolivia’s third-largest city, researching gender roles and how they affect economic development programs in that country. Eidenshink and Josephson received financial support from the Richter International Fellowship Program, which funds independent research abroad for students in SMU’s Honors Program.

Jill DeTemple, assistant professor of religious studies in Dedman College of Humanities and Sciences, served as their adviser on the research. DeTemple, whose own research examines the effects of faith-based development programs on religious identity in rural Ecuador, spent a semester helping the two students develop a research proposal. She later remained in contact with them by e-mail while they were in Bolivia.

“I am immensely proud of what they accomplished,” DeTemple says. “They applied knowledge that they learned in the classroom and developed research skills. They have made the transition from being consumers of knowledge to being creators of knowledge.”

Now a book chapter written by the students and DeTemple, describing the messages that faith-based organizations communicate about gender roles, has been accepted into an anthology under review for publication.

“Their work highlights the ways in which most development organizations and scholars presume that men and women relate to households and family life,” DeTemple says.

“While we have noted that the evangelical movement in Latin America has brought men in closer relationship to household life, Katie and Erin point out that this has not necessarily freed women to become more active in the public sector, nor has it led to gender parity in the household,” she says. “I learned a lot from their research, and will look at gender roles a little bit differently when I do my research.”

DeTemple says she also has enjoyed interesting conversations with Eidenshink and Josephson.

“Because no one else on campus is doing research in my area, I don’t have these kinds of conversations unless I go to a professional conference,” DeTemple says. “They’re working in the field now. We talk as researcher to researcher.”

Eidenshink says that working with DeTemple and conducting the research “empowered me to draw my own conclusions.”

Son%20Rissing.jpgIn addition, DeTemple “challenged us to look at the research that already had been done and then to analyze it based on what we had seen,” says Josephson, a President’s Scholar. “We found that the facts were complex, not simple and straightforward,” she says.

From cheerleader to colleague
Christiana Rissing, a Ph.D. student in SMU’s Chemistry Department, studies the interaction of dendrimers based on a tetravinylsilane core with metals like copper, platinum and silver. Any interesting properties that develop “could prove useful for medical and electronic applications,” she explains.

If she has any questions, Rissing can call on Associate Professor of Chemistry David Son, her adviser. She began studying with Son as an undergraduate and stayed at SMU to pursue her Ph.D. because she enjoys working with him.
David Son advises Christiana Rissing.

“In the lab, we’re always teasing Son about his favorite line: ‘It looks promising,'” Rissing says. “He always looks for and finds the silver lining. I can work on a stubborn experiment for weeks, and I start questioning my technique. Even when the results look bad, he will look at all the data and find something that ‘looks promising.’ It makes me want to go that extra step, read that extra paper or search through the literature in case I’ve missed something.”

As a Ph.D. student, Rissing works independently, Son says.

“I treat her more like a colleague now. But, in the beginning, with any student, you have to be a cheerleader,” he says. “When I was a graduate student, more than half of my reactions didn’t work. A big part of my role is to be an encourager.”

The research opportunityphysicist.jpg
Junior Amy Hand is writing a computer program to design a solenoid magnet that students will use in the physics lab to study the properties of “muons,” electron-like radioactive particles produced in Earth’s upper atmosphere. A solenoid magnet is made by wrapping copper wire in a pattern around a specially shaped mechanical frame to produce a uniform magnetic field within the frame’s interior.

Hand, a President’s Scholar, chose to study at SMU because of research opportunities made available to undergraduates, she says.

“Working with a professor who has so much more experience and can guide me through a project is a huge benefit,” Hand says.

Amy Hand learns the ropes in the physics lab
from Tom Coan.

Tom Coan, associate professor of physics and Hand’s adviser, helps students to develop a broad set of skills, from learning how to solder to selecting and purchasing mechanical and electrical components.

“There are a lot of practical things and a bewildering assortment of things that students have to learn to be efficient in a lab,” Coan says.

Hand researches, tests and refines the various components of her project, working closely with Coan to devise solutions as issues arise.

“The best way to learn the nitty-gritty details is elbow to elbow with a mentor,” Coan says. “It’s like an apprenticeship. You have to invest a fair amount of your time working with a student before you see any return, but the work can be beneficial to both of us.”

Planting The Seed Of Research
Stegall%2C%20Willis%2C%20Krueger.jpgSophomore Jason Stegall spent last summer in the Laser Micromachining Laboratory of the Bobby B. Lyle School of Engineering using a laser process called micromachining to cut tiny channels on material that can be used to make artificial bones.

“I was testing to see how strong the laser needed to be and how many pulses were required per task,” Stegall says.

Jason Stegall (center) in the lab with David
Willis (left) and Paul Krueger.

A National Science Foundation grant awarded to David Willis and Paul Krueger, associate professors of mechanical engineering, supported Stegall’s research. The three-year grant funds summer research opportunities for nine undergraduate students through 2009.

Through such grants the federal government is trying to encourage more students to conduct research and go to graduate school in engineering and the sciences, Willis says.

“Part of the reason more students don’t go to graduate school is that they don’t know what researchers do, and don’t understand all the opportunities that are available to researchers,” he says.

Stegall says he eventually wants to become a college professor and do research and development for the automotive or aerospace industries.

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Torrey Rick’s research involves excavating sites as old as 10,000 years on the Channel Islands off the California coast.

“The work I do is extremely collaborative,” says Rick, assistant professor of anthropology. “Students are an important part of this work, helping to complete field and laboratory analysis and often providing fresh ideas and perspectives. Conducting research also benefits students by showing them how to navigate the world of scholarly publication. Ultimately, doing research and publishing papers can help them secure an academic position.” – Joy Hart

Torrey Rick (center) and Ph.D. students Amanda Aland
and Christopher Wolff.

Related links:
Jill DeTemple
David Son
Tom Coan
David Willis
Paul Krueger
Torrey Rick
Office of Research Administration
SMU Research: Celebrating and Investing in Research at SMU

Categories
Culture, Society & Family Health & Medicine Student researchers

Happy families can help child fight obesity

An estimated 18 percent of adolescents in the U.S. are overweight or obese. Robert Hampson, associate professor of psychology in Dedman College, wants to know what role families can play in reducing that rate.

In collaboration with The Cooper Institute and the Family Studies Center at UT Southwestern Medical Center, and with funding from the Hogg Foundation for Mental Health, Hampson has been comparing two group interventions for obese girls and their families.

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After 16 weeks, neither group saw significant changes in body-mass index, but both reduced daily caloric intake.

“We learned that education does help and that mothers in particular were glad to be involved in their daughters’ treatment,” says Hampson, who is also director of graduate studies. “Perhaps in the long run, the change in eating behavior will prove more important than short-term body-mass index loss.”

The study showed, as hypothesized, that family competence, by such measures as healthy emotional interaction and teamwork, had some impact on body-mass index. There were, however, unexpected differences across racial groups: White girls in the highest-functioning families lost the most weight, while African-Americans gained, regardless.

“Going forward, we’ll look at tailoring the intervention to the racial group, and some families will need more individualized help,” Hampson says.

Related links:
Robert Hampson
Heather Kitzman
SMU Department of Psychology
The Cooper Institute
Family Studies Center at UT Southwestern Medical Center
Hogg Foundation for Mental Health
Dedman College of Humanities and Sciences

Categories
Culture, Society & Family Health & Medicine Mind & Brain Student researchers

Family Research Center helps children of family violence

Each year more than 1 million children in the United States are brought to shelters to escape family violence. Each of their families reports, on average, more than 60 acts of aggression at home during the past year, ranging from pushes and shoves to hits and kicks. More than half of the families report an incident involving a knife or gun.

“Research that studies children who witness violence in the home is fundamental to helping them,” says Paige Flink, executive director of The Family Place in Dallas. The Family Research Center, a new program of SMU’s Psychology Department in Dedman College, works with shelters such as The Family Place to address the mental health problems of children facing domestic violence.

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Family violence affects children’s physical health as well, says Candyce Tart, a second-year Ph.D. student in SMU’s clinical psychology program. Tart’s years of experience in pediatric nursing, mostly in inner-city school environments, sparked an interest in the psychology of her patients’ families.

“Many of these children’s illnesses were made worse by stress at home,” she says. “All sorts of psychological factors in their lives seemed to impact their lives more than physical health.”

Tart studies conduct-disordered children from dysfunctional or abusive families through the Family Research Center as part of her dissertation on biological and physiological underpinnings of behavioral problems.

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“I’d like to know why some children come out of these violent households with more behavior or emotional problems, and others more resilient,” she says.

SMU’s faculty, especially its revitalized clinical psychology program under Psychology Department Chair Ernest Jouriles, had a lot to do with Tart’s decision to attend the University, she says.

“Ernest Jouriles is developing a fantastic research program with the facilities and support for doing research,” says Tart. “We have so much equipment available, as well as access into shelters and other community and clinical locations. And it’s a very collaborative environment. Not all schools have that.”

Related links:
Family Research Center
Candyce Tart
Ernest Jouriles
Department of Psychology
The Family Place
Dedman College of Humanities and Sciences