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Earth & Climate Economics & Statistics Plants & Animals

Biodiversity: Some species may always be endangered

Once hunted to near-extermination, the Northern Rocky Mountain gray wolf reached an important milestone recently. With a population estimated at 1,500, the wolf re-established itself in the Yellowstone National Park area, and in March 2008 the U.S. Fish and Wildlife Service removed it from protection under the Endangered Species Act.

Almost immediately, hunters began petitioning the state offices of Idaho, Montana and Wyoming for permits to hunt the wolves, perhaps down to as little as 20 percent of their current numbers in some areas. Such a weighty issue begs the questions: How much hunting is safe for a given species? How many gray wolves can die before the species loses its chance at recovery?

Gray Wolf. Credit: John & Karen Hollingsworth/USFWS

Understanding the market forces that drive these environmental decisions is a vital yet missing piece of public policy on natural resource management, says Santanu Roy, SMU professor of economics in Dedman College and 2007-08 SMU Ford Research Fellow.

An expert in dynamic economic models and microeconomic theory, Roy focuses on the economics of natural resources and the environment.

Central to Roy’s model for managing biological species is a concern about how population size and uncertainty affect the flow of benefits and costs from the harvesting of resources and what it means for conservation and extinction when resources are managed optimally over time.

“The traditional model of biological harvesting usually considers only the market value and benefits of using these resources,” he says. “But there is an increasing consciousness of the value of biodiversity, that a species might be very valuable someday because of the biodiversity it helps provide.”

The traditional view of natural resources in general, and of biological species in particular, is as an investment asset, as something speculators can own or privatize, liquidate or conserve, Roy adds.

“These simple comparisons have to be abandoned,” he says.

As an example, Roy focuses on the critically endangered blue whale. Suppose an individual gained the right to own the entire stock of blue whales in the oceans, he says.

“If the blue whale population were doubling every year, it would be worth conserving from an investment standpoint. But, at present, it is growing at only 2 percent to 5 percent a year,” Roy says. “If you take all the available blue whales now, sell them at market price, put the money in the bank and enjoy the interest for the rest of your’s and your children’s lives, that’s more money than you could make by cultivating whales forever.”

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Gray Wolf. Credit: Tracy Brooks/Mission Wolf.

But this approach fails to consider several factors unique to species, he says.

“There are peculiar challenges that come from the biological side of the story,” Roy says. “And these challenges must become part of the equation.”

One is the possibility of what biologists call depensation, if a population becomes too small, it collapses and cannot grow anymore.

“The International Whaling Commission basically stopped all harvesting of blue whales 30 years ago,” he says, “but the population hasn’t recovered. They don’t meet each other to mate that often.”

Another factor in Roy’s model is stock dependence of cost.

“If you take $100 out of your checking account and have a party, the enjoyment you get will not depend upon how much money you have left in the bank,” he says.

Roy%201.jpg“That’s not true for biological species, which become more and more costly to harvest as their populations shrink,” Roy says. This is one reason why species like the blue whale, almost paradoxically, stop losing their numbers once they are near extinction, he adds.

“If you’ve ever gone fishing,” Roy says, “you know that it’s very difficult to fish if there are very few of them.”

Conversely, if a population is large, its harvesting cost becomes small — a condition that took a toll on the American bald eagle in the past century, Roy says. Protections for the bird allowed its population to grow rapidly. The resulting easy harvesting gave hunters an incentive to drive them nearly to extinction.

“When a population increases, at some point it sharply decreases, because it becomes very economical to harvest,” he says. “These are the critical moments at which species can become extinct.”

Roy hopes his research will help steer public policy toward more intelligent management of biological issues, especially regarding extinction, he says. The U.S. government has long held “safe standards,” meaning the point at which a population is greater than a size critical to survival, as its conservation yardstick. But Roy’s work has shown that “some species may never be safe,” he says.

“The thing most lacking in public policy right now is that it doesn’t understand individual cases,” he adds. “We need to take much more of the available scientific information into account. What’s good for one species is not good for another.”

Roy, who joined SMU in 2003, earned his Ph.D. degree from Cornell University. He has published his work in the “Journal of Economic Theory” and other publications. — Kathleen Tibbetts

Related links:
SMU: Economics of extinction
Santanu Roy
USFWS: Gray Wolf news, info and recovery status reports
USFWS Video: Gray Wolvesvideo.jpg
SMU Department of Economics
Dedman College of Humanities and Sciences

Categories
Health & Medicine Plants & Animals

Pound-for-pound, chihuahuas and children expend more energy

If you’ve ever visited a dog park, you may have noticed that a chihuahua tires much more quickly than a German shepherd. That does not occur just because a small dog takes more steps to cover the same amount of ground, says Peter Weyand, associate professor of applied physiology and biomechanics in SMU’s Annette Caldwell Simmons School of Education and Human Development.

In his research into animal and human physiology, Weyand has studied the impact of such factors as muscular force and the amount of time limbs are in contact with the ground on the energy cost of walking and running.

webWeyand_Peter.gifHis years of research on creatures ranging from goats to antelopes to kangaroos indicate that smaller animals expend much more energy per pound to locomote. For example, a mouse expends 30 times more energy than an elephant in proportion to their weights, while human children use about twice as much energy as their parents to cover the same distance, he says.

Weyand and colleagues have found that one of the essential determinants of energy expenditure, fatigue rates and performance is the amount of time muscles are active to apply force to the ground, bicycle pedals or other external objects.

“This holds true whether you are a chihuahua, a German shepherd, Usain Bolt or a couch potato,” he says. Shorter times mean higher rates of energy expenditure and more rapid fatigue, but they are also necessary for high-end performance.

Now the holder of a patent on his methods, Weyand has explained the limits of human and animal running performance for the History Channel, CNN, the Canadian Broadcasting Corporation, NHK Television Japan and a host of other media outlets. He monitored sprinter Michael Johnson’s running mechanics in a special feature for NBCOlympics.com during the 2000 Athens games and has provided live commentary for the Boston Marathon.

Weyand’s research is funded in part by the U.S. Army Medical Research and Materiel Command, which hopes to develop quick methods to assess and monitor soldiers’ physical fitness to help improve their overall healthcare. He’s also helping to develop a new SMU undergraduate major in applied physiology and sports management.

Related links:
TIME Magazine: How Fast Can Humans Go?
The Times of India: Diet not a factor in sprinter’s speed
Peter Weyand
Annette Caldwell Simmons School of Education and Human Development

Categories
Energy & Matter Health & Medicine Plants & Animals Student researchers

Aids, cancer targeted by biology researchers

In his third-floor laboratory in Dedman Life Sciences Building, biologist Robert Harrod and his team are zeroing in on a new way to inhibit the virus that causes AIDS. They already have shown that their approach, which involves the rare genetic disorder Werner syndrome, works when the disorder’s enzyme defect is introduced into cells.

Now they are trying to find practical ways to use this pathway to inhibit the AIDS virus. The beauty of this approach is that the AIDS virus will not be able to mutate in a way that can defeat this treatment, says Harrod, associate professor in the Biological Sciences Department of Dedman College.

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Down the hall from Harrod’s lab, Assistant Professor of Biological Sciences Jim Waddle is preparing to file for a patent on a tiny “worm” that is expected to be highly useful in drug-testing, producing results far more quickly than tests run on larger lab creatures.

Meanwhile, their colleagues, Associate Professor Pia Vogel and her husband, John Wise, a lecturer in the Biological Sciences Department, are conducting work that may have implications for cancer treatment.

In university laboratories throughout the world, enormous strides have been made in biology research in recent years, including the mapping of the human genome. With young faculty members like Harrod, Waddle and Vogel working on cutting-edge conundrums, and a recent $3.6 million gift to Biological Sciences, SMU’s department is poised to play a high-profile role in biology advances in coming years, says William Orr, chair and professor of biological sciences.

The gift from philanthropist and SMU Board of Trustees member Caren Prothro and the Perkins-Prothro Foundation includes $2 million for an endowed chair, $1 million for an endowed research fund, $500,000 for a graduate fellowship fund and $100,000 for an undergraduate scholarship fund.

The endowment will enable the University to attract a biologist with a national reputation in research to join a faculty that is strong in cellular and molecular biology and biochemistry and is doing research that could have practical applications in medicine, Orr says.

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For example, Vogel and Wise are looking for a way to improve the long-term efficacy of chemotherapy treatments. Wise uses a nautical metaphor to explain their work: “Picture a cancer cell as a ship on a sea and the chemotherapy being dumped into the ship, there’s a mechanism like a sump pump that will dump that chemical back overboard,” he says.

That cellular “sump pump” is important to normal cell health because it keeps toxins out.

“Of course, with cancer cells that are targeted for destruction by chemotherapeutics, you’d like to be able to turn off that mechanism,” Wise adds.

John Wise

Vogel explains that many cancer cells respond to treatment by pumping out more and more of the toxins as time goes on, so that a cancer treatment that works well initially might not work as well in later stages.

“Switching chemotherapy drugs doesn’t help because the cancer cells just pump out everything, resulting in multi-drug resistance,” she says.

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Using Electron Spin Resonance Spectroscopy, a biophysical technique that obtains structural information about the cellular pump, Vogel’s research group is trying to find a way to shut off the ATP energy usage by this cellular sump pump.

“If you can knock out the pump, you can sink the cancer ship,” she says.

Harrod, who studies retroviruses that infect humans and who is focusing on transcriptional gene regulation, is working on a mechanism that might sidestep a more specific type of multidrug resistance — of the virus that causes AIDS to the conventional HAART (highly active antiretroviral treatment) drug regimen.

Pia Vogel

His approach is related to a rare genetic disorder called Werner syndrome, which causes premature aging in those who have the disease. Researchers have noted that individuals who are carriers for Werner syndrome do not develop AIDS. Harrod hypothesized that the enzyme involved in Werner syndrome is necessary for transcription of the retrovirus.

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Using cells that had the Werner syndrome defect inserted into them, his lab was able to confirm this link, and last year he and co-researchers published the findings in “The Journal of Biological Chemistry.” Now his group is looking for molecules that might be used to block this transcription-necessary enzyme. Included among the researchers cited in the journal article were several biological sciences students. Both graduate and undergraduate students assisted Harrod in his lab work on retroviral transcription.

Ask Assistant Professor Jim Waddle about the contributions made by students, and he’ll talk about the weird “worm” discovered by one of his graduate students. Waddle, whose Ph.D. work was in molecular genetics, has been studying the nematode Caenorhabditis elegans as a model for food absorption in the human gut.

Fingerlike projections called microvilli, which are necessary for the absorption of nutrients, line the human gut; nematodes have microvilli on every gut cell.

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As part of their research, Waddle’s lab doused the nematodes in mutation-causing chemicals and examined them via a fluorescent protein.

Ph.D. candidate Christina Paulson looked at 20,000 nematodes in this manner and came up with one that had a nematode version of diverticulosis, with outpouchings all along the gut.

Disappointingly, the mutated worm turned out to be normal in terms of lifespan, reproduction and absorption of nutrients. But, Waddle says, “we threw our heads together and thought about conditions the nematode might encounter in the wild” versus the laboratory setting. He wondered if the worm might have trouble eliminating toxins. It did.

Jim Waddle

Normal nematodes eliminate toxins too quickly for the worms to be useful in drug testing, but toxins stay in the weird worms long enough to have an effect on them. And that means the millimeter-long creature likely will be highly useful in drug-testing situations, because a nematode’s life cycle is so much shorter than that of the larger animals, such as mice, that generally are used to test drugs.

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The student who identified the worm is one of 18 graduate students in the Department of Biological Sciences. Nine are working on Master’s degrees, nine on Ph.Ds. With 126 undergraduates, the department enrolls the largest segment of undergraduate majors in the natural sciences at SMU. Undergraduate students who intend to go into biological research can apply for the BRITE (Biomedical Researchers in Training Experience) program, a collaboration between SMU and the University of Texas Southwestern Medical Center that leads to acceptance into a UT Southwestern Ph.D. program.

Orr believes the department is poised for a leap forward in size and stature. Administrative support to boost research has come from Provost Paul Ludden, whose background is in biochemistry. Current research projects are supported by $4.3 million from agencies that include the National Institutes of Health and the National Science Foundation.
Christina Paulson

Orr’s dream for the department is to double the current tenured and tenure-track faculty to 18 members. Of the nine, seven conduct ongoing research projects, five of which are funded by federal agencies. The department will add an assistant professor in spring 2009. Later that year, a national search will be conducted to fill the new Distinguished Chair of Biological Sciences.

william.jpgAlthough the department is small, a synergy has developed from building a faculty that is focused on cellular and molecular biochemistry, Orr says.

Researchers can work together on projects, brainstorming ideas for new areas of investigation. More grants can be applied for, which means more grants awarded.

“We have a strong group that is focused on certain areas. By adding new faculty we will be able to boost the overall stature of the department,” Orr says. “If we increase the academic stature and the amount of research, we can provide more opportunities for graduate students and for undergraduates. It all works together.” — Cathy Frisinger

William Orr

Related links:
Robert Harrod
Jim Waddle
Pia Vogel
John Wise
William Orr
Biological Sciences Department
Dedman College of Humanities and Sciences

Categories
Health & Medicine Plants & Animals Technology

Jellyfish, squid propulsion aid new “micro” vehicle research

The movement of aquatic life can appear inexplicable when viewed through the glass of an aquarium tank.
But Paul Krueger believes the mechanics that jellyfish and squid use to maneuver can be applied to technology in the emerging field of “micro” vehicles.
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Krueger, associate professor in the SMU Bobby B. Lyle School of Engineering‘s Department of Mechanical Engineering, is studying a mechanical system similar to that used by jellyfish and squid to understand pulsatile propulsion and apply it to exotic engineering applications like micropropulsion. Krueger’s research results eventually might propel tiny vehicles — sizes of a centimeter, millimeter or smaller — used in microsurgery, create micro-submarines for undersea caverns exploration, or maneuver small aircraft for military surveillance.

“Small flight-capable or submersible vehicles are of great technological interest because their diminutive size permits increased portability and access to otherwise inaccessible locations,” Krueger says.

Creating new propulsion schemes is “paramount to the design of micro vehicles because traditional propulsion designs, such as propellers and steady jets, become too inefficient at small scales,” he says.

image002.jpgKrueger believes that pulsed jets, consisting of a series of jet pulses with no flow between them, is a promising approach to developing micropropulsion capability. He plans to develop a model system that propels itself using pulsed jets generated by a volume-displacement mechanism. The behavior of this representative vehicle will help reveal how to adapt pulsed jet propulsion for small-scale vehicles.

Krueger’s research is being supported through a five-year, $400,000 Faculty Early Career Development award from the National Science Foundation, partially because of its multidisciplinary nature and potential for educating pre-college students.

As part of the research, he is collaborating with a biologist who is an expert on squid biomechanics, enhancing cross-disciplinary efforts between the fields of biology and mechanical engineering.

Krueger also plans to incorporate the study of micropropulsion devices and its applications to biology, marine life, and medical applications into introductory material for mechanical engineering courses.

“Illustrating applications of mechanical engineering in different fields may be a key factor in attracting new students from various backgrounds to study mechanical engineering,” he says.

Krueger joined the SMU Lyle School of Engineering in 2002. He received his B.S. in mechanical engineering in 1997 from the University of California at Berkeley. Krueger received his Ph.D. in aeronautics in 2001 from the California Institute of Technology.

Related links:
Paul Krueger
Paul Krueger research site
Lyle School Experimental Fluid Dynamics Laboratory
Bobby B. Lyle School of Engineering
Berkeley Engineering: SMU hires Paul Krueger