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Self-persuasion iPad app spurs low-income parents to protect teens against cancer-causing hpv

In the first study of its kind, self-persuasion software on an iPad motivated low-income parents to want to protect their teens against the cancer-causing human papillomavirus

As health officials struggle to boost the number of teens vaccinated against the deadly human papillomavirus, a new study from Southern Methodist University, Dallas, found that self-persuasion works to bring parents on board.

Currently public health efforts rely on educational messages and doctor recommendations to persuade parents to vaccinate their adolescents. Self-persuasion as a tool for HPV vaccinations has never been researched until now.

The SMU study found that low-income parents will decide to have their teens vaccinated against the sexually transmitted cancer-causing virus if the parents persuade themselves of the protective benefits.

The study’s subjects — almost all moms — were taking their teens and pre-teens to a safety-net pediatric clinic for medical care. It’s the first to look at changing parents’ behavior through self-persuasion using English- and Spanish-language materials.

“This approach is based on the premise that completing the vaccination series is less likely unless parents internalize the beliefs for themselves, as in ‘I see the value, I see the importance, and because I want to help my child,’” said psychology professor Austin S. Baldwin, a principal investigator on the research.

Depending on age, the HPV vaccine requires a series of two or three shots over eight months. External pressure might initially spark parents to action. But vaccinations decline sharply after the first dose.

The new study follows an earlier SMU study that found guilt, social pressure or acting solely upon a doctor’s recommendation was not related to parents’ motivation to vaccinate their kids.

The new finding is reported in the article “Translating self-persuasion into an adolescent HPV vaccine promotion intervention for parents attending safety-net clinics” in the journal Patient Education and Counseling.

Both studies are part of a five-year, $2.5 million grant from the National Cancer Institute. Baldwin, associate professor in the SMU Department of Psychology, is co-principal investigator with Jasmin A. Tiro, associate professor in the Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas.

Addressing the HPV problem
A very common virus, HPV infects nearly one in four people in the United States, including teens, according to the Centers for Disease Control. HPV infection can cause cervical, vaginal and vulvar cancers in females; penile cancer in males; and anal cancer, back of the throat cancer and genital warts in both genders, the CDC says.

The CDC recommends a series of two shots of the vaccine for 11- to 14-year-olds to build effectiveness in advance of sexual activity. For 15- to 26-year-olds, they are advised to get three doses over the course of eight months, says the CDC.

Currently, about 60% of adolescent girls and 40% of adolescent boys get the first dose of the HPV vaccine. After that, about 20% of each group fail to follow through with the second dose, Baldwin said.

The goal set by health authorities is to vaccinate 80% of adolescents to achieve the herd immunity effect of indirect protection when a large portion of the population is protected.

NCI grant aimed at developing a software app
The purpose of the National Cancer Institute grant is to develop patient education software for the HPV vaccine that is easily used by low-income parents who may struggle to read and write, and speak only Spanish.

A body of research in the psychology field has shown that the technique of self-persuasion among well-educated people is successful using written English-language materials. Self-persuasion hasn’t previously been tested among underserved populations in safety-net clinics.

The premise is that individuals will be more likely to take action because the choice they are making is important to them and they value it.

In contrast, where motivation is extrinsic, an individual acts out of a sense of others’ expectations or outside pressure.

Research has found that people are much more likely to maintain a behavior over time — such as quitting smoking, exercising or losing weight — when it’s autonomously motivated. Under those circumstances, they value the choice and consider it important.

“A provider making a clear recommendation is clearly important,’” said Deanna C. Denman, a co-author on the study and a graduate researcher in SMU’s Psychology Department. “Autonomy over the decision can be facilitated by the doctor, who can confirm to parents that “The decision is yours, and here are the reasons I recommend it.’”

Doctor’s recommendation matters, but may not be sufficient
For the SMU study, the researchers educated parents in a waiting room by providing a custom-designed software application running on an iPad tablet.

The program guided the parents in English or Spanish to scroll through audio prompts that help them think through why HPV vaccination is important. The parents verbalized in their own words why it would be important to them to get their child vaccinated. Inability to read or write wasn’t a barrier.

Parents in the SMU study were recruited through the Parkland Memorial Hospital’s out-patient pediatric clinics throughout Dallas County. Most of the parents were Hispanic and had a high school education or less. Among 33 parents with unvaccinated adolescents, 27 — 81% — decided they would vaccinate their child after completing the self-persuasion tasks.

New study builds on prior study results
In the earlier SMU study, researchers surveyed 223 parents from the safety-net clinics. They completed questionnaires relevant to motivation, intentions and barriers to vaccination.

The researchers found that autonomous motivation was strongly correlated with intentions, Denman said. As autonomous motivation increased, the greater parents’ intentions to vaccinate. The lower the autonomous motivation, the lower the parents’ intentions to vaccinate, she explained.

“So they may get the first dose because the doctor says it’s important,” Baldwin said. “But the second and third doses require they come back in a couple months and again in six months. It requires the parent to feel it’s important to their child, and that’s perhaps what’s going to push or motivate them to complete the series. So that’s where, downstream, there’s an important implication.”

Other co-authors on the study are Margarita Sala, graduate student in the SMU Psychology Department; Emily G. Marks, Simon C. Lee and Celette Skinner, who along with Tiro are at the University of Texas Southwestern Medical Center and the Harold C. Simmons Comprehensive Cancer Center in Dallas; L. Aubree Shay, U.T. School of Public Health, San Antonio; Donna Persaud and Sobha Fuller, Parkland Health & Hospital System, Dallas; and Deborah J. Wiebe, University of California-Merced, Merced, Calif.

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Huffington Post: A New Physics Discovery Could Make You A Faster Runner

It’s all about the force

Reporter Sarah DiGiullo with the online news magazine The Huffington Post covered the research of Peter Weyand and the SMU Locomotor Laboratory. Weyand, who is Glenn Simmons Professor of Applied Physiology and professor of biomechanics in the Department of Applied Physiology and Wellness in SMU’s Annette Caldwell Simmons School of Education and Human Development, is the director of the Locomotor Lab.

Other authors on the study were Laurence Ryan, a physicist and research engineer in the lab, and
Kenneth Clark , previously with the lab and now an assistant professor in the Department of Kinesiology at West Chester University in West Chester, Penn.

The three have developed a concise approach to understanding the mechanics of human running. The research has immediate application for running performance, injury prevention, rehab and the individualized design of running shoes, orthotics and prostheses. The work integrates classic physics and human anatomy to link the motion of individual runners to their patterns of force application on the ground — during jogging, sprinting and at all speeds in between.

The Huffington Post article, “Researchers reveal the mechanics of running is simpler than thought – and it could revolutionize shoe design,” published Feb. 13, 2017.

Read the full story.

EXCERPT:

By Sarah DiGiullo
The Huffington Post

When it comes to race day, runners may have favorite moisture-wicking gear, a stopwatch and tunes to help get that coveted personal record.

But physicists say running at your top speed may actually be a lot simpler. It all comes down to the force of your foot striking the ground ― and that’s about it.

After studying the physics behind some of the world’s fastest runners, researchers came up with a new model they say could make anyone faster. It may help injured runners recover faster, too.

The researchers developed an equation that calculates two forces: The total force of the shin, ankle and foot striking the ground, and the total force of the rest of the body striking the ground. The method, which they detailed in an article published recently in the Journal of Experimental Biology, can predict how fast an athlete will run.

“We’ve known for quite some time that fast people are fast because they’re able to hit the ground harder in relation to how much they weigh,” explained the study’s co-author, Peter Weyand, director of the Locomotor Performance Laboratory at Southern Methodist University in Dallas.

But Weyand and his team were looking to better understand why it was that some people are able to hit the ground harder than others. The new equation makes the answer a lot clearer, with fewer measurements than previous models.

Read the full story.

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New delta Scuti: Rare pulsating star 7,000 light years away is 1 of only 7 in Milky Way

A star — as big as or bigger than our sun — in the Pegasus constellation is expanding and contracting in three different directions simultaneously on a scale of once every 2.5 hours, the result of heating and cooling of hydrogen fuel burning 28 million degrees Fahrenheit at its core

The newest delta Scuti (SKOO-tee) star in our night sky is so rare it’s only one of seven identified by astronomers in the Milky Way. Discovered at Southern Methodist University in Dallas, the star — like our sun — is in the throes of stellar evolution, to conclude as a dying ember in millions of years. Until then, the exceptional star pulsates brightly, expanding and contracting from heating and cooling of hydrogen burning at its core.

Astronomers are reporting a rare star as big — or bigger — than the Earth’s sun that is expanding and contracting in a unique pattern in three different directions.

The star is one that pulsates and so is characterized by varying brightness over time. It’s situated 7,000 light years away from the Earth in the constellation Pegasus, said astronomer Farley Ferrante, a member of the team that made the discovery at Southern Methodist University, Dallas.

Called a variable star, this particular star is one of only seven known stars of its kind in our Milky Way galaxy.

“It was challenging to identify it,” Ferrante said. “This is the first time we’d encountered this rare type.”

The Milky Way has more than 100 billion stars. But just over 400,900 are catalogued as variable stars. Of those, a mere seven — including the one identified at SMU — are the rare intrinsic variable star called a Triple Mode ‘high amplitude delta Scuti’ (pronounced SKOO-tee) or Triple Mode HADS(B), for short.

“The discovery of this object helps to flesh out the characteristics of this unique type of variable star. These and further measurements can be used to probe the way the pulsations happen,” said SMU’s Robert Kehoe, a professor in the Department of Physics who leads the SMU astronomy team. “Pulsating stars have also been important to improving our understanding of the expansion of the universe and its origins, which is another exciting piece of this puzzle.”

The star doesn’t yet have a common name, only an official designation based on the telescope that recorded it and its celestial coordinates. The star can be observed through a telescope, but identifying it was much more complicated.

A high school student in an SMU summer astronomy program made the initial discovery upon culling through archived star observation data recorded by the small but powerful ROTSE-I telescope formerly at Los Alamos National Laboratory in New Mexico.

Upon verification, the star was logged into the International Variable Star Index as ROTSE1 J232056.45+345150.9 by the American Association of Variable Star Observers at this link.

How in the universe was it discovered?
SMU’s astrophysicists discovered the variable star by analyzing light curve shape, a key identifier of star type. Light curves were created from archived data procured by ROTSE-I during multiple nights in September 2000. The telescope generates images of optical light from electrical signals based on the intensity of the source. Data representing light intensity versus time is plotted on a scale to create the light curves.

Plano Senior High School student Derek Hornung first discovered the object in the ROTSE-I data and prepared the initial light curves. From the light curves, the astronomers knew they had something special.

It became even more challenging to determine the specific kind of variable star. Then Eric Guzman, a physics graduate from the University of Texas at Dallas, who is entering SMU’s graduate program, solved the puzzle, identifying the star as pulsating.

“Light curve patterns are well established, and these standard shapes correspond to different types of stars,” Ferrante said. “In a particular field of the night sky under observation there may have been hundreds or even thousands of stars. So the software we use generates a light curve for each one, for one night. Then — and here’s the human part — we use our brain’s capacity for pattern recognition to find something that looks interesting and that has a variation. This allows the initial variable star candidate to be identified. From there, you look at data from several other nights. We combine all of those into one plot, as well as add data sets from other telescopes, and that’s the evidence for discerning what kind of variable star it is.”

That was accomplished conclusively during the referee process with the Variable Star Index moderator.

The work to discover and analyze this rare variable star was carried out in conjunction with analyses by eight other high school students and two other undergraduates working on other variable candidates. The high school students were supported by SMU’s chapter of the Department of Energy/National Science Foundation QuarkNet program.

Heating and cooling, expanding and contracting
Of the stars that vary in brightness intrinsically, a large number exhibit amazingly regular oscillations in their brightness which is a sign of some pulsation phenomenon in the star, Ferrante said.

Pulsation results from expanding and contracting as the star ages and exhausts the hydrogen fuel at its core. As the hydrogen fuel burns hotter, the star expands, then cools, then gravity shrinks it back, and contraction heats it back up.

“I’m speaking very generally, because there’s a lot of nuance, but there’s this continual struggle between thermal expansion and gravitational contraction,” Ferrante said. “The star oscillates like a spring, but it always overshoots its equilibrium, doing that for many millions of years until it evolves into the next phase, where it burns helium in its core. And if it’s about the size and mass of the sun — then helium fusion and carbon is the end stage. And when helium is used up, we’re left with a dying ember called a white dwarf.”

Within the pulsating category is a class of stars called delta Scuti, of which there are thousands. They are named for a prototype star whose characteristic features — including short periods of pulsating on the scale of a few hours — are typical of the entire class.

Within delta Scuti is a subtype of which hundreds have been identified, called high amplitude delta Scuti, or HADS. Their brightness varies to a particularly large degree, registering more than 10 percent difference between their minimum and maximum brightness, indicating larger pulsations.

Common delta Scuti pulsate along the radius in a uniform contraction like blowing up a balloon. A smaller sub-category are the HADS, which show asymmetrical-like pulsating curves.

Within HADS, there’s the relatively rare subtype called HADS(B) , of which there are only 114 identified.

Star evolution — just a matter of time
A HADS(B) is distinguished by its two modes of oscillation — different parts of the star expanding at different rates in different directions but the ratio of those two periods is always the same.

For the SMU star, two modes of oscillation weren’t immediately obvious in its light curve.

“But we knew there was something going on because the light curve didn’t quite match known light curves of other delta Scuti’s and HADS’ objects we had studied. The light curves — when laid on top of each other — presented an asymmetry,” Ferrante said. “Ultimately the HADS(B) we discovered is even more unique than that though — it’s a Triple Mode HADS(B) and there were previously only six identified in the Milky Way. So it has three modes of oscillation, all three with a distinct period, overlapping, and happening simultaneously.”

So rare, in fact, there’s no name yet for this new category nor a separate registry designation for it. Guzman, the student researcher who analyzed and categorized the object, recalled how the mystery unfolded.

“When I began the analysis of the object, we had an initial idea of what type it could be,” Guzman said. “My task was to take the data and try to confirm the type by finding a second period that matched a known constant period ratio. After successfully finding the second mode, I noticed a third signal. After checking the results, I discovered the third signal coincided with what is predicted of a third pulsation mode.”

The SMU Triple Mode HADS(B) oscillates on a scale of 2.5 hours, so it will expand and contract 10 times in one Earth day. It and the other known six HADS(B)’s are in the same general region of the Milky Way galaxy, within a few thousand light years of one another.

“I’m sure there are more out there,” Ferrante said, “but they’re still rare, a small fraction.”

Red giant the final phase of star’s evolution
SMU’s Triple Mode HADS(B) is unstable and further along in its stellar evolution than our sun, which is about middle-aged and whose pulsating variations occur over a much longer period of time. SMU’s Triple Mode HADS(B) core temperature, heated from the burning of hydrogen fuel, is about 15 million Kelvin or 28 million degrees Fahrenheit.

Someday, millions of years from now, SMU’s Triple Mode HADS(B) will deplete the hydrogen fuel at its core, and expand into a red giant.

“Our sun might eventually experience this as well,” Ferrante said. “But Earth will be inhospitable long before then. We won’t be here to see it.”

Funding was through the Texas Space Grant Consortium, an affiliate of NASA; SMU Dedman College. Department of Energy/National Science Foundation QuarkNet program.

ROTSE-I began operating in late 1997, surveying the sky all night, every clear night of the year for three years. It was decommissioned in 2001 and replaced by ROTSE-III. SMU owns the ROTSE-IIIb telescope at McDonald Observatory, Fort Davis, Texas.

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APS Physics: Viewpoint — Dark Matter Still at Large

“No dark matter particles have been observed by two of the world’s most sensitive direct-detection experiments, casting doubt on a favored dark matter model.” — Jodi Cooley

SMU physicist Jodi Cooley, an associate professor in the Department of Physics, writes in the latest issue of Physical Review Letters about the hunt by physicists worldwide for dark matter — the most elusive and abundant matter in our Universe.

Cooley is an expert in dark matter and a lead researcher on one of the key dark matter experiments in the world.

Cooley’s APS Physics article, “Viewpoint: Dark Matter Still at Large,” published Jan. 11, 2017.

The journal is that of the American Physical Society, a non-profit membership organization advancing knowledge of physics through its research journals, scientific meetings, education, outreach, advocacy and international activities. APS represents more than 53,000 members, including physicists in academia, national laboratories and industry in the United States and throughout the world.

Cooley’s current research interest is to improve our understanding of the universe by deciphering the nature of dark matter. The existence of dark matter was first postulated nearly 80 years ago. However, it wasn’t until the last decade that the revolution in precision cosmology revealed conclusively that about a quarter of our universe consisted of dark matter. Cooley and her colleagues operate sophisticated detectors in the Soudan Underground Laboratory in Minnesota. These detectors can distinguish between elusive dark matter particles and background particles that mimic dark matter interactions.

She received a B.S. degree in Applied Mathematics and Physics from the University of Wisconsin in Milwaukee in 1997. She earned her Masters in 2000 and her Ph.D. in 2003 at the University of Wisconsin-Madison for her research searching for neutrinos from diffuse astronomical sources with the AMANDA-II detector. Upon graduation she did postdoctoral studies at both MIT and Stanford University.

Cooley is a Principal Investigator on the SuperCDMS dark matter experiment and a Principal Investigator for the AARM collaboration, which aims to develop integrative tools for underground science. She has won numerous awards for her research including an Early Career Award from the National Science Foundation and the Ralph E. Powe Jr. Faculty Enhancement Award from the Oak Ridge Associated Universities.

She was named December 2012 Woman Physicist of the Month by the American Physical Societies Committee on the Status of Women and earned a 2012 HOPE (Honoring our Professor’s Excellence) by SMU. In 2015 she received the Rotunda Outstanding Professor Award.

Read the full article.

EXCERPT:

By Jodi Cooley
Southern Methodist University

Over 80 years ago astronomers and astrophysicists began to inventory the amount of matter in the Universe. In doing so, they stumbled into an incredible discovery: the motion of stars within galaxies, and of galaxies within galaxy clusters, could not be explained by the gravitational tug of visible matter alone [1]. So to rectify the situation, they suggested the presence of a large amount of invisible, or “dark,” matter. We now know that dark matter makes up 84% of the matter in the Universe [2], but its composition—the type of particle or particles it’s made from—remains a mystery. Researchers have pursued a myriad of theoretical candidates, but none of these “suspects” have been apprehended. The lack of detection has helped better define the parameters, such as masses and interaction strengths, that could characterize the particles. For the most compelling dark matter candidate, WIMPs, the viable parameter space has recently become smaller with the announcement in September 2016 by the PandaX-II Collaboration [3] and now by the Large Underground Xenon (LUX) Collaboration [4] that a search for the particles has come up empty.

Since physicists don’t know what dark matter is, they need a diverse portfolio of instruments and approaches to detect it. One technique is to try to make dark matter in an accelerator, such as the Large Hadron Collider at CERN, and then to look for its decay products with a particle detector. A second technique is to use instruments such as the Fermi Gamma-ray Space Telescope to observe dark matter interactions in and beyond our Galaxy. This approach is called “indirect detection” because what the telescope actually observes is the particles produced by a collision between dark matter particles. In the same way that forensic scientists rely on physical evidence to reverse-engineer a crime with no witnesses, scientists use the aftermath of these collisions to reconstruct the identities of the initial dark matter particles.

The third technique, and the one used in both the LUX and PandaX-II experiments, is known as “direct detection.” Here, a detector is constructed on Earth with a massive target to increase the odds of an interaction with the dark matter that exists in our Galaxy. In the case of LUX and PandaX-II, the dark matter particles leave behind traces of light that can be detected with sophisticated sensors. This is akin to having placed cameras at the scene of a crime, capturing the culprit in the act.

Read the full article.

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Green chemistry: Au naturel catalyst mimics nature to break tenacious carbon-hydrogen bond

Chemists discover new way to crack the stubborn carbon-hydrogen bond that could allow industry to make petroleum-derived commercial products easier, cheaper and cleaner

A new catalyst for breaking the tough molecular bond between carbon and hydrogen holds the promise of a cleaner, easier and cheaper way to derive products from petroleum, says a researcher at Southern Methodist University, Dallas.

“Some of the most useful building blocks we have in the world are simple, plentiful hydrocarbons like methane, which we extract from the ground. They can be used as starting materials for complex chemical products such as plastics and pharmaceuticals,” said Isaac Garcia-Bosch, Harold A. Jeskey Endowed Chair assistant professor in the Department of Chemistry at SMU. “But the first step of the process is very, very difficult — breaking that carbon-hydrogen bond. The stronger the bond, the more difficult it is to oxidize.”

The chemical industry must break the tenacious bond between carbon and hydrogen molecules to synthesize oxidative products such as methanol and phenols. It’s called oxidizing because it causes the molecule to undergo a reaction in which it combines with oxygen, breaking C-H bonds and forming new carbon-oxygen bonds.

The conventional chemical recipe calls for inefficient and expensive oxidants to break the C-H bond. That process is costly, difficult and leaves behind dirty waste products.

Chemists at SMU, in collaboration with The Johns Hopkins University, have found a cheaper, cleaner way to crack the stubborn C-H bond.

Garcia-Bosch and chemist Maxime A. Siegler, director of the X-ray Crystallography Facility at The Johns Hopkins University, used copper catalysts that in combination with hydrogen peroxide (oxygen source) can convert C-H bonds to C-O bonds.

“This is a very important discovery because it’s the first time it’s been proven that copper can carry out this kind of oxidation outside of nature in an efficient way,” Garcia-Bosch said. “The prep is very simple, so labs anywhere can do it. Copper is relatively cheap compared to other metals such as palladium, gold or silver, and hydrogen peroxide is readily available, relatively cheap and very clean. One of the byproducts of oxidations with hydrogen peroxide (H2O2) is water (H2O), which is the cleanest waste product you could have.”

Additionally, the researchers found the right ligand — a nitrogen-based material that binds to the copper so that the oxidation process can occur with close to perfect efficiency.

It’s important to have the right ligand, the right amount of hydrogen peroxide, and the right metal in order to oxidize these challenging C-H bonds.

“We found that combination,” Garcia-Bosch said.

Chemistry is like a puzzle, where you build new molecules out of other molecules, he said.

In any one molecule there are many C-H bonds. For example in octanes, such as the ones found in gasoline, there’s a carbon chain of eight carbons with multiple C-H bonds with different chemical properties, Garcia-Bosch said, and from the oxidation of each of the C-H bonds, a different product results.

Chemists design catalysts that are capable of breaking and forming bonds in order to build complex chemical structures.

“Catalysts have to be able to select between different C-H bonds and form new carbon-oxygen, carbon-nitrogen or carbon-fluoride bonds, for example,” Garcia-Bosch said. “Biological processes use metals to do this all the time, for example in our bodies when our liver processes a pharmaceutical that we ingest using iron. Minerals such as iron, copper, manganese, calcium and potassium are critical for the natural catalytic process. For example, trees use manganese (photosynthesis) to transform water into the oxygen that we breathe”

Garcia-Bosch and Siegler reported their findings in the article “Copper-Catalyzed Oxidation of Alkanes with H2O2 under a Fenton-like Regime,” published in the international edition of the journal Angewandte Chemie.

First time for using copper for C-H oxidation
In organic chemistry, there aren’t many examples of copper as a catalyst for carbon-hydrogen oxidation. Most examples are based on iron.

“This is the first time in our field that we’ve used copper to do this C-H oxidation in a very efficient way,” Garcia-Bosch said.

“Copper is very versatile in nature,” he said. “With small changes in the environment of copper, you can do very diverse chemistry. That’s why we picked it.”

That environment is the ligand, which gives properties to the copper to spark the chemical reaction when the chemical ingredients are combined in a vial or round bottom flask.

The researchers discovered that these catalysts — copper in the form of a white salt and the ligand as an oil — can oxidize C-H bonds in a very efficient way in combination with hydrogen peroxide, a reduced form of oxygen that nature uses.

“You can find hydrogen peroxide anywhere, even at home in your medicine cabinet. So it’s a mild oxidant,” Garcia-Bosch said. “It’s convenient also, because it’s a liquid, rather than, say, a gas, which might require special storage. You mix everything together in a solvent and it reacts. It’s like making a soup, a recipe, then you analyze the result to see what you get.”

Using a gas chromatography instrument, the Garcia-Bosch and Siegler analyzed the final solution to observe the results of the reaction. That allowed them to quantify the amount of oxidation product that was formed during the reaction.

Next step — targeting a specific C-H bond
“We tested this catalytic system for different substrates and we saw that it’s not very selective,” Garcia-Bosch said. “That’s a problem. So if we have molecules that have many different C-H bonds, then it’s going to oxidize all of them in a non-selective manner. In our lab, we would like to find selective catalysts. That’s the next project.”

Garcia-Bosch holds the Harold A. Jeskey Endowed Chair in Chemistry. The research was funded through The Robert A. Welch Foundation (Grant N-1900).