DALLAS (SMU) – Seems like smartphones can do everything these days. Add to that list gathering information on bridge’s structural health.
Brett Story, assistant professor of civil and environmental engineering at SMU’s Lyle School of Engineering, and students at Garland High School are using smartphones in passing cars to check if there are any cracks or uneven settling in the foundation of the Briarwood bridge, which crosses over Duck Creek in Garland.
The Dallas Morning News has more on this innovative research.
About SMU
SMU is the nationally ranked global research university in the dynamic city of Dallas. SMU’s alumni, faculty and nearly 12,000 students in seven degree-granting schools demonstrate an entrepreneurial spirit as they lead change in their professions, communities and the world.
Volcanic eruptions and their ash clouds pose a significant hazard to population centers and air travel, especially those that show few to no signs of unrest beforehand. Geologists are now using a technique traditionally used in weather and climate forecasting to develop new eruption forecasting models. By testing if the models are able to capture the likelihood of past eruptions, the researchers are making strides in the science of volcanic forecasting.
The study, published in the journal Geophysical Research Letters, examined the eruption history of the Okmok volcano in Alaska. In 2008, a large eruption produced an ash plume that extended approximately 1 mile into the sky over the Aleutian Islands – posing a significant hazard to aircraft engines along a route that transports roughly 50,000 people between Asia and North America each day, the researchers said.
“The 2008 eruption of Okmok came as a bit of surprise,” said University of Illinois graduate student and lead author Jack Albright. “After an eruption that occurred in 1997, there were periods of slight unrest, but very little seismicity or other eruption precursors. In order to develop better forecasting, it is crucial to understand volcanic eruptions that deviate from the norm.”
Geologists typically forecast eruptions by looking for established patterns of preeruption unrest such as earthquake activity, groundswell and gas release, the researchers said. Volcanoes like Okmok, however, don’t seem to follow these established patterns.
To build and test new models, the team utilized a statistical data analysis technique developed after World War II called Kalman filtering.
“The version of Kalman filtering that we used for our study was updated in 1996 and has continued to be used in weather and climate forecasting, as well as physical oceanography,” said U. of I. geology professor Patricia Gregg, a co-author of the study that included collaborators from SMU (Southern Methodist University) and Michigan State University. “We are the first group to use the updated method in volcanology, however, and it turns out that this technique works well for the unique unrest that led up to Okmok’s 2008 eruption.”
One of those unique attributes is the lack of increased seismicity before the eruption, the researchers said. In a typical preeruption sequence, it is hypothesized that the reservoir under the volcano stays the same size as it fills with magma and hot gases. That filling causes pressure in the chamber to increase and the surrounding rocks fracture and move, causing earthquakes.
“In the 2008 eruption, it appears that the magma chamber grew larger to accommodate the increasing pressure, so we did not see the precursor seismic activity we would expect,” Albright said. “By looking back in time with our models, or hindcasting, we can now observe that stress had been building up in the rocks around the chamber for weeks, and the growth of the magma system ultimately led to its failure and eruption.”
This type of backward and forward modeling allows researchers to watch a volcanic system evolve over time. “While we stopped our analysis after the 2008 eruption, we are now able to propagate this new model forward in time, bring it to present day, and forecast where Okmok volcano is heading next,” Gregg said.
The researchers posit that these models will continue to find other less-recognized eruption precursors, but acknowledge that every volcano is different and that the models must be tailored to fit each unique system.
The volcano forecasting technique used in this study was based on volcano deformation data from GPS and satellite radars. Geophysicist Zhong Lu, a professor in the Roy M. Huffington Department of Earth Sciences at SMU and a global expert in satellite radar imagery analysis, processed the satellite radar images and provided the volcano deformation maps for this research.
The U. of I. team is working in collaboration with researchers from Alaska Volcano Observatory and SMU to help build a stronger forecasting system for the Aleutian Islands area. The researchers received $541,921 in grant money from NASA for the work in early 2019.
UT Southwestern Medical Center and SMU found migratory birds maximize how much light they get from their environment, so they can migrate even at night
DALLAS (SMU) – It was a puzzle about birds.
Migratory birds are known to rely on Earth’s magnetic field to help them navigate the globe. And it was suspected that a protein called cryptochrome, which is sensitive to blue light, was making it possible for birds to do this.
Yet many of these animals are also known to migrate at night when there isn’t much light available. So it wasn’t clear how cryptochrome would function under these conditions in birds.
A new study led by UT Southwestern Medical Center in collaboration with SMU (Southern Methodist University), though, may have figured out the answer to that puzzle.
Researchers found that cryptochromes from migratory birds have evolved a mechanism that enhances their ability to respond to light, which can enable them to sense and respond to magnetic fields.
“We were able to show that the protein cryptochrome is extremely efficient at collecting and responding to low levels of light,” said SMU chemist Brian D. Zoltowski, who was one of the lead authors of a new study on the findings. “The result of this research is that we now understand how vertebrate cryptochromes can respond to very low light intensities and function under night time conditions.”
The study was published in the journal PNAS in September.
Cryptochromes are found in both plants and animals and are responsible for circadian rhythms in various species. In birds, scientists were specifically focused on learning more about an unusual eye protein called CRY4, which is part of a class of cryptochromes.
The lab of Joseph Takahashi, a circadian rhythms expert at UT Southwestern Medical Center, worked with other UT Southwestern scientists to purify and solve the crystal structure of the protein – the first atomic structure of a photoactive cryptochrome molecule from a vertebrate. The lab of Brian Zoltowski, an expert in blue-light photoreceptors, studied the efficiency of the light-driven reactions – identifying a pathway unique to CRY4 proteins that facilitates function under low light conditions.
“Although in plants and insects, cryptochromes are known to be photoactive, which means they react to sunlight. Among vertebrates much less is known, and the majority of vertebrate cryptochromes do not appear to be photoactive,” said Takahashi, chairman of neuroscience at UT Southwestern and an investigator with Howard Hughes Medical Institute. “This photosensitivity and the possibility that CRY4 is affected by the magnetic field make this specific cryptochrome a very interesting molecule.”
Researchers took a sample of the CRY4 from a pigeon and grew crystals of the protein. They then exposed the crystals to x-rays, making it possible for them to map out the location of all the atoms in the protein.
And while pigeons are not night-migratory songbirds, the sequences of their CRY4 proteins are very similar, the study noted.
“These structures allow us to visualize at the atomic scale how these proteins function and understand how they may use blue-light to sense magnetic fields,” said Zoltowski, associate professor of chemistry at SMU’s Dedman College of Humanities & Sciences. “The new structures also provide the first atomic level detail of how these proteins work, opening the door for more detailed studies on cryptochromes in migratory organisms.”
In the study, researchers discovered unusual changes to key regions of the protein structure that can enhance their ability to collect light from their environment.
“Cryptochromes work by absorbing a photon of light, which causes an electron to move through a sequence of amino acids. These amino acids typically consist of a chain of 3 or 4 sites that act as a wire that electrons can flow through,” explained Zoltowski. “But in pigeons, it was identified that this chain may be extended to contain 5 sites.”
This mutation of the electron chain in pigeons makes cryptochrome less dependent on a bird’s environment having a lot of light for the protein to be activated.
“Birds have evolved a mechanism to enhance the efficiency. So even when there is very little light around, they have enough signal generated to migrate,” Zoltowski said.
Other co-authors of the study include UT Southwestern’s Yogarany Chelliah, Anushka Wickramaratne, Wei Xu, Ryan E. Hibbs and Carla B. Green; SMU’s Nischal Karki; Henrik Mouritsen from the University of Oldenburg; and Peter J. Hore and Lauren Jarocha from the University of Oxford.
About SMU
SMU is the nationally ranked global research university in the dynamic city of Dallas. SMU’s alumni, faculty and nearly 12,000 students in seven degree-granting schools demonstrate an entrepreneurial spirit as they lead change in their professions, communities and the world.
The ambassadors are encouraged to share their stories of being women innovators, in hopes it inspires the next generation of women to get into science, technology, engineering and math [STEM]
DALLAS (SMU) – SMU (Southern Methodist University) graduate Myria Perez ’18 was one of 125 women innovators across the country who was selected to be an AAAS IF/THEN ambassador.
Their mission? To share their stories and serve as high-profile role models for girls, in hopes it leads to a new generation of women getting into science, technology, engineering and math [STEM].
“We firmly believe that if we support a woman in STEM, then she can change the world,” Lyda Hill, the founder of Lyda Hill Philanthropies, said in a statement. “The goal of IF/THEN is to shift the way our country — and the world — think about women in STEM and this requires changing the narratives about women STEM professionals and improving their visibility.”
Perez, who is now a fossil preparator at the Perot Museum, worked with paleontologist Louis Jacobs and others to unearth never-before-seen fossils from Angola. Those fossils are currently on display at Smithsonian’s National Museum of Natural History.
Learn more about Perez in this video, Myria Perez: Portrait of a Paleontologist. You can also read about the award she won in The Dallas Morning News article.
About SMU
SMU is the nationally ranked global research university in the dynamic city of Dallas. SMU’s alumni, faculty and nearly 12,000 students in seven degree-granting schools demonstrate an entrepreneurial spirit as they lead change in their professions, communities and the world.
New SMU study may provide insight on how our brains are able to produce so many different types of neurons, which control everything we do
DALLAS (SMU) – SMU (Southern Methodist University) researchers have discovered another layer of complexity in gene expression, which could help explain how we’re able to have so many billions of neurons in our brain.
Neurons are cells inside the brain and nervous system that are responsible for everything we do, think or feel. They use electrical impulses and chemical signals to send information between different areas of the brain, and between the brain and the rest of the nervous system, to tell our body what to do. Humans have approximately 86 billion neurons in the brain that direct us to do things like lift an arm or remember a name.
Yet only a few thousand genes are responsible for creating those neurons.
All cells in the human nervous system have the same genetic information. But ultimately, genes are turned “on” or “off” like a light switch to give neurons specific features and roles. Understanding the mechanism of how a gene is or is not turned on – the process known as gene expression – could help explain how so many neurons are developed in humans and other mammals.
“Studies like this are showing how by unique combinations of specific genes, you can make different specific neurons,” said Adam D. Norris, co-author of the new study and Floyd B. James Assistant Professor in the Department of Biological Sciences at SMU. “So down the road, this could help us explain: No. 1, how did our brain get this complex? And No. 2, how can we imitate nature and make whatever type of neurons we might be interested in following these rules?”
Scientists already have part of the gene expression puzzle figured out, as previous studies have shown that proteins called transcription factors play a key role in helping to turn specific genes on or off by binding to nearby DNA.
It is also known that a process called RNA splicing, which is controlled by RNA binding proteins, can add an additional layer of regulation to that neuron. Once a gene is turned on, different versions of the RNA molecule can be created by RNA splicing.
But before the SMU study was done, which was published in the journal eLife, it was not exactly clear what the logistics of creating that diversity was.
“Before this, scientists had mostly been focused on transcription factors, which is layer No. 1 of gene expression. That’s the layer that usually gets focused on as generating specific neuron types,” Norris said. “We’re adding that second layer and showing that [transcription factors and RNA binding proteins] have to be coordinated properly.
And Norris noted, “this was the first time where coordination of gene expression has been identified in a single neuron.”
Using a combination of old school and cutting-edge genetics techniques, researchers looked at how the RNA of a gene called sad-1, also found in humans, was spliced in individual neurons of the worm Caenorhabditis elegans. They found that sad-1 was turned on in all neurons, but sad-1 underwent different splicing patterns in different neuron types.
And while transcription factors were not shown to be directly participating in the RNA splicing for the sad-1 gene, they were activating genes that code for RNA binding proteins differently between different types of neurons. It is these RNA binding proteins that control RNA splicing.
“Once that gene was turned on, these factors came in and subtly changed the content of that gene,” Norris said.
As a result, sad-1 was spliced according to neuron-specific patterns.
They also found that the coordinated regulation had different details in different neurons.
“Picture two different neurons wanting to reach the same goal. You can imagine they either go through the exact same path to get there or they take divergent paths. In this study, we’re showing that the answer so far is divergent paths,” said Norris. “Even in a single neuron, there are multiple different layers of gene expression that together make that neuron the unique neuron that it is.”
Norris used worm neurons because “unlike in humans, we know where every worm neuron is and what it should be up to. Therefore, we can very confidently know which genes are responsible for which neural process.
“The very specific details from this study will not apply to humans. But hopefully the principles involved will,” Norris explained. “From the last few decades of work in the worm nervous system, specific genes found to have a specific effect on the worm’s behavior were later shown to be responsible for the same types of things in human nerves.”
The lead author of the study was Morgan Thompson, a graduate student at SMU. Ryan Bixby, Robert Dalton, Alexa Vandenburg — all former or current students in SMU’s Biological Sciences department — also contributed to the study. In addition, John A. Calarco from the University of Toronto, Canada was a co-author.
About SMU
SMU is the nationally ranked global research university in the dynamic city of Dallas. SMU’s alumni, faculty and nearly 12,000 students in seven degree-granting schools demonstrate an entrepreneurial spirit as they lead change in their professions, communities and the world.