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DNA from 31,000-year-old human teeth reveals new ethnic group living in Siberia during last Ice Age

An international team of researchers, including SMU anthropologist David Meltzer, discovered a new group of ancient Siberians. The research was published June 5, 2019 as a story in Nature

Two children’s milk teeth buried deep in a remote archaeological site in north eastern Siberia have revealed a previously unknown group of people lived there during the last Ice Age.

The finding was part of a wider study, which also discovered 10,000 year-old human remains in another site in Siberia are genetically related to Native Americans – the first time such close genetic links have been discovered outside of the US.

The two 31,000-year-old milk teeth found at the Yana Rhinoceros Horn Site in Russia which led to the discovery of a new group of ancient Siberians. Photo credit: Russian Academy of Sciences.

The international team of scientists, led by Professor Eske Willerslev who holds positions at St John’s College, University of Cambridge, and is director of The Lundbeck Foundation Centre for GeoGenetics at the University of Copenhagen, have named the new people group the ‘Ancient North Siberians’ and described their existence as ‘a significant part of human history’.

The DNA was recovered from the only human remains discovered from the era – two tiny milk teeth – that were found in a large archaeological site found in Russia near the Yana River. The site, known as Yana Rhinoceros Horn Site (RHS), was found in 2001 and features more than 2,500 artifacts of animal bones and ivory along with stone tools and evidence of human habitation.

The discovery was published on June 5 as part of a wider study in Nature and shows the Ancient North Siberians endured extreme conditions in the region 31,000 years ago and survived by hunting woolly mammoths, woolly rhinoceroses, and bison. Several publications, such as The New York Times and Science Magazine, also covered the discovery.

Professor Willerslev said: “These people were a significant part of human history, they diversified almost at the same time as the ancestors of modern day Asians and Europeans and it’s likely that at one point they occupied large regions of the northern hemisphere.”

Dr Martin Sikora, of The Lundbeck Foundation Centre for GeoGenetics and first author of the study, added: “They adapted to extreme environments very quickly, and were highly mobile. These findings have changed a lot of what we thought we knew about the population history of north eastern Siberia but also what we know about the history of human migration as a whole.”

Researchers estimate that the population numbers at the site would have been around 40 people with a wider population of around 500. Genetic analysis of the milk teeth revealed the two individuals sequenced showed no evidence of inbreeding which was occurring in the declining Neanderthal populations at the time.

The complex population dynamics during this period and genetic comparisons to other people groups, both ancient and recent, are documented as part of the wider study which analyzed 34 samples of human genomes found in ancient archaeological sites across northern Siberia and central Russia.

Professor Laurent Excoffier from the University of Bern, Switzerland, said: “Remarkably, the Ancient North Siberians people are more closely related to Europeans than Asians and seem to have migrated all the way from Western Eurasia soon after the divergence between Europeans and Asians.”

Scientists found the Ancient North Siberians generated the mosaic genetic make-up of contemporary people who inhabit a vast area across northern Eurasia and the Americas – providing the ‘missing link’ of understanding the genetics of Native American ancestry.

It is widely accepted that humans first made their way to the Americas from Siberia into Alaska via a land bridge spanning the Bering Strait which was submerged at the end of the last Ice Age. The researchers were able to pinpoint some of these ancestors as Asian people groups who mixed with the Ancient North Siberians.

One of the paper’s senior authors, Professor David Meltzer from Southern Methodist University (SMU), explained: “We gained important insight into population isolation and admixture that took place during the depths of the Last Glacial Maximum – the coldest and harshest time of the Ice Age – and ultimately the ancestry of the peoples who would emerge from that time as the ancestors of the indigenous people of the Americas.” Meltzer is an anthropologist at SMU’s Dedman College of Humanities & Sciences.

This discovery was based on the DNA analysis of a 10,000 year-old male remains found at a site near the Kolyma River in Siberia. The individual derives his ancestry from a mixture of Ancient North Siberian DNA and East Asian DNA, which is very similar to that found in Native Americans. It is the first time human remains this closely related to the Native American populations have been discovered outside of the US.

Professor Willerslev added: “The remains are genetically very close to the ancestors of Paleo-Siberian speakers and close to the ancestors of Native Americans. It is an important piece in the puzzle of understanding the ancestry of Native Americans as you can see the Kolyma signature in the Native Americans and Paleo-Siberians. This individual is the missing link of Native American ancestry.” — St. John’s College, University of Cambridge

Read The New York Times article here. More publications on the discovery can be found here:

A 31,000-year-old milk tooth was discovered in this small area among ancient remnants of tools and animal bones. Photo credit: Elena Pavlova

 

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CBS 7: Research shows Permian Basin sinkholes are growing

DALLAS (SMU) – SMU geophysicist Zhong Lu was interviewed by CBS-7’s Shane Battis to discuss the ongoing issue of West Texas sinking.

So far, two large sinkholes have formed near Wink, Texas. But Lu notes that the problem is only expected to get worse over time, due to the Permian Basin in Wink and other neighboring towns having a layer of salt below the ground. In many cases, oil and gas drilling has allowed leaking water to soften that salt layer and cause the surface to cave in, Lu explained.

Lu and fellow SMU geophysicist Jin-Woo Kim have done a series of studies on the phenomenon of the ground sinking at alarming rates in West Texas.  Earlier studies have revealed significant ground movement that suggests the two existing holes are expanding and new ones are forming.

The researchers used satellite radar images that were made public by the European Space Agency, and supplemented that with oil activity data from the Railroad Commission of Texas.

Lu and Kim are both in the SMU’s Roy M. Huffington Department of Earth Sciences, which is part of the Dedman College of Humanities & Sciences.

As Lu told Battis, the deterioration can cause serious problems for people in Wink.

“I think if you live in that area, I would be very concerned,” he said.

For instance, he noted that sinking ground can bend roads into unsafe shapes that put drivers and risk, and it can also damage pipelines underground.

Watch the CBS-7 news segment. 

 

EXCERPT

WINK, Tx. (KOSA) – Research by geophysics has shown the Permian Basin may be booming economically, but it’s also sinking physically.

Wink is known for its massive sinkhole, but new research suggests that in the coming years that sight might not be so uncommon.

It turns out Wink isn’t the only spot prone to sinkholes.

Researchers at Southern Methodist University have found points all over the Permian Basin where the ground is sinking at 5 to 53 centimeters every year.

But why?

CBS7 spoke to a Dr. Zhong Lu, a geophysics professor at SMU who has been studying sinkholes patterns in the Permian Basin.

He explained the Permian Basin has a layer of salt below the ground surface and in many instances oil and gas drilling has allowed leaking water to soften that layer and cause the surface to cave in.

“The casings on the oil wells, it has problems and it cracks and leaks through the casing,” Lu said. “And the corrosion of the metal pipe may also be happening as well that allows the water to diffuse into that area.”

 

About SMU

SMU is the nationally ranked global research university in the dynamic city of Dallas. SMU’s alumni, faculty and nearly 12,000 students in seven degree-granting schools demonstrate an entrepreneurial spirit as they lead change in their professions, communities and the world.

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Dallas Cowboys’ legend and video gamers help fight cancer

Gamer’s play contributes to SMU research

The worlds of eSports, professional sports, philanthropy and cancer researching collided on Saturday for an online streaming event to raise funds for children with cancer, their families and Children’s Health in Dallas.

Three-time Super Bowl winner and NFL Hall of Famer, Michael Irvin, and two-time Madden NFL champion, Drini Gjoka, joined to compete in a gaming tournament alongside patients and patient families at Children’s Medical Center Dallas. The tournament consisted of a live Madden NFL 19 streaming game via Twitch and ExtraLife. Stream viewers were asked to make contributions to Children’s Health in support of its Dallas emergency room renovation.

At the same time, technology created by BALANCED Media | Technology helped Southern Methodist University (SMU) researchers search for a cure for cancer.

The event was also made possible by esports organization Complexity Gaming, which streamed the tournament via its channels and provided social media, press and corporate connections.  Other collaborators included The Playmakers Academy of young athletes and Still Thankful LLC, a bridge for medical families and their support group that wants to help.

NBC-5’s Paul Jones covered the event, which was followed by more than 13,000 people.

Video Game Was Fun, Also Helped Cancer Researchers

Not only did the Dallas Cowboys’ Irvin and Gjoka help earn thousands of dollars for families affected by cancer, but a Twitch interactive gamed called Omega Cluster also allowed people watching the gaming tournament to help SMU researchers.

In the Omega Cluster game, each player acted as a spaceship pilot who must warp from location to location gathering energy crystals before enemies’ lock onto their position and destroy their ship. The process of collecting and sorting crystals was actually sorting by proxy a set of chemotherapeutic co-medications compounds that have been tested in the SMU Center for Drug Discovery, Design and Delivery’s laboratory. The game let players explore these compounds and identify what has allowed some to be successful in lab testing while others have not.

BALANCED’s HEWMEN, meanwhile, continually supplied all of the game players with the best-known solutions each time a player launched Omega Cluster. This synchronization ensured that the video gaming community was always working to help push the science to the next level by searching and sorting the best-known solutions for any further improvements.

“If they just play that game…that’s actually helping us try to find those compounds that can actually make incurable cancer treatable and that’s what the goal is, what we’re working towards,” Corey Clark told NBC. Clark, the deputy director of research at SMU Guildhall and director of the Human and Machine Intelligence (HuMIn) Game Lab, designed the game with the help of research from biochemistry professors John Wise and Pia Vogel.

Not the First Time SMU Has Worked With Gamers To Help Cure Cancer

It’s not the first time Wise and Vogel have worked with Clark to narrow the search for cancer-fighting chemotherapy drugs.

They also partnered with the makers of “Minecraft” to create a version of the popular best-selling video game that could help SMU researchers identify which chemical compounds show promise in alleviating the problem of chemotherapy failure after repeated use.

The Vogel and Wise research labs are part of the Center for Drug Discovery, Design and Delivery (CD4) in SMU’s Dedman College.  Source: SMU, Play It Forward eSports

About SMU

SMU is the nationally ranked global research university in the dynamic city of Dallas. SMU’s alumni, faculty and nearly 12,000 students in seven degree-granting schools demonstrate an entrepreneurial spirit as they lead change in their professions, communities and the world.

 

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The Dallas Morning News: HMS, Australia team up to solve a global health challenge

DALLAS (SMU) – Southern Methodist University (SMU) has teamed up with Texas-based HMS, the Digital Health CRC (Cooperative Research Centre) and Stanford University to tackle some of the world’s most significant health challenges using ‘big data.’ Dallas Morning News’ business reporter Melissa Repko covered the news on the collaboration, which was announced on Tuesday.

There are two key health care challenges that the coalition is looking to address: the global opioid epidemic and the high rates of avoidable hospital readmissions. The first research project conducted by Stanford University students will tackle the opioid crisis. The second project—led by Daniel Heitjan, Chair of Statistical Science at SMU—will focus on preventable hospital readmissions, which is when patients unexpectedly return to a hospital within 30 days of an earlier hospital stay.

As Repko reported, HMS is providing a key piece of the puzzle: A massive database of more than 2 million patients that researchers can use to find patterns and flag people who are at risk. Researchers will use the Medicaid claims data that HMS clients agree to share. It will be stripped of personal details such as names and addresses that could identify a patient.

Created last year by the Australian government with a seven-year grant, the Digital Health CRC is comprised of more than 80 businesses, universities and health technology providers. Its goal, working with HMS, SMU and Stanford University, is to develop and test digital health solutions that will solve “a vexing problem for both the U.S. and Australia: Health care costs that are skyrocketing, even as outcomes lag behind,” Repko wrote.

Victor Pantano, chief executive of Digital Health CRC, said the immensity and significance of the project reminds him of the Apollo space program. He lives in Canberra, the Australian capital. It’s near a former NASA tracking station called Honeysuckle Creek. The tracking station — a collaboration between scientists in the U.S. and Australia — received and relayed to the world the first images of astronaut Neil Armstrong walking on the moon.

 

Researchers from the two countries are partnering again to explore “one of the most exciting frontiers in the modern age: the use of big data and digital technologies to deliver better health systems and better health outcomes into the future,” he said.

Read the Dallas Morning News article here.  

About SMU

SMU is the nationally ranked global research university in the dynamic city of Dallas. SMU’s alumni, faculty and nearly 12,000 students in seven degree-granting schools demonstrate an entrepreneurial spirit as they lead change in their professions, communities and the world.

 

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KERA News: ‘Teaching joy’ is a new approach in the battle against anhedonia

DALLAS (SMU) – Anhedonia is a symptom of depression that strips people of their ability to feel joy.

Alicia Meuret and Thomas Ritz, professors at Southern Methodist University (SMU), talked to KERA News’ host of All Things Considered Justin Martin about why this psychological condition can be so devastating for people who have it.

Meuret, professor of psychology and director of SMU’s Anxiety and Depression Research Center, and Ritz, an SMU professor of psychology, have been part of a five-year study that aims to develop a more effective treatment for anhedonia.  UCLA is also part of that study.

Listen to KERA interview.

About SMU

SMU is the nationally ranked global research university in the dynamic city of Dallas. SMU’s alumni, faculty and nearly 12,000 students in seven degree-granting schools demonstrate an entrepreneurial spirit as they lead change in their professions, communities and the world.