August 30, 2021

Researchers at SMU have found a way to make chemotherapy drugs more lethal to HPV-infected cervical cancer cells without collateral damage to normal cells, a study suggests.

Decreasing the amount of a protein called TIGAR in cervical cancer cells was found to make those cancer cells more responsive to commonly-used chemotherapy drugs at a very low dose. Yet normal cells were not similarly affected, according to a study recently published in the Journal of Antivirals & Antiretrovirals.

As a result, developing a drug to target the TIGAR protein could be an effective way to lower chemotherapy doses for cervical cancer patients, bringing fewer side-effects while still killing cancer cells. Chemotherapy drugs can have severe side effects, including liver and kidney toxicities, because these drugs may harm normal cells as well as cancer cells.

Read more at SMU Research.