Publications

Google Scholar Page for Dr. Lippert

55. Kagalwala, H. N.; Lippert, A. R. Energy Transfer Chemiluminescent Spiroadamantane 1,2-Dioxetane Probes for Bioanalyte Detection and Imaging.” Angew. Chem. Int. Edit. 2022, Accepted Article. doi: 10.1002/anie.202210057

54. Kagalwala, H. N.; Reeves, R. T.; Lippert, A. R. “Chemiluminescent spiroadamantane-1,2-dioxetanes: Recent advances in molecular imaging and biomarker detection.” Curr. Opin. Chem. Biol. 2022, 68, 102134. doi: 10.1016/j.cbpa.2022.102134

Image 1

53. Digby, E. M.; Tung, M. T.; Kagalwala, H. N.; Ryan, L. S.; Lippert, A. R.; Beharry, A. A. “Dark Dynamic Therapy: Photosensitization without Light Excitation Using Chemiluminescence Resonance Energy Transfer in a Dioxetane-Erythrosin B Conjugate.” ACS Chem. Biol. 2022, Early View. doi: 10.1021/acschembio.1c00925

Abstract Image

52. Kagalwala, H. N.; Gerberich, J.; Smith, C. J.; Mason, R. P.; Lippert, A. “Chemiluminescent 1,2-Dioxetane Iridium Complexes for Near-Infrared Oxygen Sensing.” Angew. Chem. Int. Ed. 2022, online publication. doi: 10.1002/anie.202115704

51. Chandrasiri, I.; Yaddehige, M. L.; Li, B.; Sun, Y.; Meador, W. E.; Dorris, A.; Zia, M. F.; Hammer, N. I.; Flynt, A.; Delcamp, J. H.; Davis, E.; Lippert, A.; Watkins, D. L. “Cross-linking Poly(caprolactone)-Polyamidoamine Linear Dendritic Block Copolymers for Thernostic Nanomedicine.” ACS Appl. Polym. Mater. 2022, online publication. doi: 10.1021/acsapm.1c01131

50. Haris, U.; Plank, J. T.; Li, B.; Page, Z. A.; Lippert, A. R. “Visible Light Chemical Micropatterning Using a Digital Light Processing Fluorescence Microscope.” ACS Cent. Sci. 2021, online publication. doi: 10.1021/acscentsci.1c01234

49. Li, B.; Kim, Y. J.; Lippert, A. R. “Chemiluminescence Measurement of Reactive Sulfur and Nitrogen Species.” Antioxid. Redox Signal. 2021, online publication. doi: 10.1089/ars.2021.0195

48. Haris, U.; Kagalwala, H. N.; Kim, Y. J.; Lippert, A. R. “Seeking Illumination: The Path to Chemiluminescent 1,2-Dioxetanes for Quantitative Measurements and In Vivo Imaging.” Acc. Chem. Res. 2021, 54, 2844-2857. doi: 10.1021/acs.accounts.1c00185

47. Ritz, T.; Salsman, M. L.; Young, D. A.; Lippert, A. R.; Khan, D. A.; Ginty, A. T. “Boosting nitric oxide in stress and respiratory infection: Potential relevance for asthma and COVID-19.” Brain Behav. Immun. Health 2021, 14, 100255. doi: 10.1016/j.bbih.2021.100255.

46. Lefton, J. B.; Pekar, K. B.; Haris, U., Zick, M. E.; Milner, P. J.; Lippert, A. R.; Pejov, L; Runcevski, T. “Defect formation and amorphization of Zn-MOF-74 crystals by post-synthetic interactions with bidentate adsorbates.” J. Mater. Chem. A 2021, 9, 19698-19704 . doi: 10.1016/10.1039/DOTA10613E.

45. Ryan, L. S.; Nakatsuka, A.; Lippert, A. R. “Photoactivatavle 1,2-dioxetane chemiluminophores.” Results in Chemistry 2021, 3, 100106. doi: 10.1016/j.rechem.2021.100106.

44. Li, B.; Haris, U.; Aljowni, M.; Nakatsuka, A.; Patel, S. K.; Lippert, A. R. “Tuning the Photophysical Properties of Spirolactam Rhodamine Photoswitches.” Isr. J. Chem. 2021, 61, 242-252. doi: 10.10002/ijch.202000083. Journal Cover Art

43. Bunton, C. B.; Bassampour, Z. M.; Boothby, J. M.; Smith, A. N.; Rose, J. V.; Nguyen, D. M.; Ware, T. H.; Csaky, K. G.; Lippert, A. R.; Tsarevsky, N. V.; Son, D. Y. “Degradable Silyl Ether–Containing Networks from Trifunctional Thiols and Acrylates.” Macromolecules 2020, 53, 9890-9900. doi: 10.1021/acs.macromol.0c01967

42. Quimbar, M. E.; Davis, S. Q.; Al-Farra, S. T.; Hayes, A.; Jovic, V.; Masuda, M.; Lippert, A. R. “Chemiluminescent Measurement of Hydrogen Peroxide in Exhaled Breath Condensate of Healthy and Asthmatic Adults.” Anal. Chem. 2020, 92, 14594-14600. doi: 10.1021/acs.analchem.0c02929

41. Ryan, L. S.; Gerberich, J.; Haris, U.; Nguyen, D.; Mason, R. P.; Lippert, A. R. “Ratiometric pH Imaging Using a 1,2-Dioxetane Chemiluminescence Resonance Energy Transfer Sensor in Live Animals.” ACS Sens. 2020, 5, 2925-2932. doi: 10.1021/acssensors.0c01393; ChemRxiv 2020, link

40. Bezner, B. J.; Ryan, L. S.; Lippert, A. R. “Reaction-Based Luminescent Probes for Reactive Sulfur, Oxygen, and Nitrogen Species: Analytical Techniques and Recent Progress.” Anal. Chem. 2020, 92, 309-326. doi: 10.1021/analchem.9b04990

39. Wise, J. G.; Nanayakkara, A. M.; Aljowni, M.; Chen, G.; De Oliveira, M. C.; Ammerman, L.; Olengue, K.; Lippert, A. R.; Vogel, P. D. “Optimizing Targeted Inhibitors of P-Glycoprotein Using Computational and Structure-Guided Approaches.” J. Med. Chem. 2019, 62, 10645-10663. doi: 10.1021/acs.jmedchem.9b00966

38. Worth, R. C.; Mizrachi, A.; Li, H.; Markovsky, E.; Enyedi, B.; Jacobi, J.; Brodsky, O.; Cao, J.; Lippert, A. R.; Incrocci, L.; Mulhall, J. P.; Haimovitz-Friedman, A. “Sildenafil Protects Endothelial Cells from Radiation-Induced Oxidative Stress.” J. Sex. Med. 2019, 16, 1721-1733. doi: 10.1016/j.jsxm.2019.08.015

 

37. Jones, K. A.; Kentala, K.; Beck, M. W.; An. W.; Lippert, A. R.; Lewis, J. C.; Dickinson, B. C. “Development of a Split Esterase for Protein-Protein Interaction-Dependent Small-Molecule Activation.” ACS Cent. Sci. 2019, 5, 1768–1776. doi: 10.1021/acscentsci.9b00567

36. Ryan, L. S.; Gerberich, J. L.; Cao, J.; An, W.; Jenkins, B. A.; Mason, R. P.; Lippert, A. R. “Kinetics-Based Measurement of Hypoxia in Living Cells and Animals Using an Acetoxymethyl Ester Chemiluminescent Probe.” ACS Sens. 2019, 4, 1391-1398. doi: 10.1021/acssensors.9b00360

35. An, W.; Ryan, L. S.; Reeves, A. G.; Bruemmer, K. J.; Mouhaffel, M.; Gerberich, J. L.; Winters, A.; Mason, R. P.; Lippert, A. R. “A Chemiluminescent Probe for HNO Quantification and Real-time Monitoring in Living Cells.” Angew. Chem. Int. Edit. 2019, 58, 1361-1365. doi:10.1002/anie.201811257

34. Woods, J. J.; Cao, J.; Lippert, A. R.; Wilson, J. J. “Characterization and Biological Activity of a Hydrogen-Sulfide Releasing Red Light-Activated Ruthenium(II) Complex.” J. Am. Chem. Soc. 2018, 140, 12383-12387. doi:10.1021/jacs.8b08695

33. An, W.; Mason, R. P.; Lippert, A. R. “Energy Transfer Chemiluminescence for Ratiometric pH Imaging.” Org. Biomol. Chem. 2018, 16, 4176-4182. doi:10.1039/C8OB00972D

32. Cao, J.; An, W.; Reeves, A. G.; Lippert, A. R. “A Chemiluminescent Probe for Cellular Peroxynitrite Using a Self-Immolative Oxidative Decarbonylation Reaction.” Chem. Sci. 2018, 9, 2552-2558. doi:10.1002/anie.201711228

31. Ryan, L. S; Lippert, A. R. “Ultrasensitive Chemiluminescent Detection of Cathepsin B: Insights into the New Frontier of Chemiluminescent Imaging.” Angew. Chem. 2018, 57, 622-624. doi:10.1002/anie.201711228 (Highlight Article)

30. Patel, S. K.; Cao, J.; Lippert, A. R. “A Volumetric Digital Light 3D Photoactivatable Dye Display.” Nature Commun. 2017, 15239. doi:10.1039/C7AY01238A [SMU Research] [EurekAlert!] [Phys.Org] [NovusLight] [Optics & Photonics News] [Cosmos Magazine] [Digital Trends]

29. Kroll, J. L.; Werchan, C. A.; Reeves, A. G.; Bruemmer, K. J.; Lippert, A. R.; Ritz, T. “Sensitivity of salivary hydrogen sulfide to psychological stress and its association with exhaled nitric oxide and affect.” Physiol. Behav. 2017, 179, 99-104. doi:10.1016/j.physbeh.2017.05.023

28. Reeves, A. G.; Subbarao, M.; Lippert, A. R. “Imaging acetaldehyde formation during ethanol metabolism in living cells using a hydrazine naphthalimide fluorescent probe.” Anal. Methods 2017, 9, 3418-3421. doi:10.1039/C7AY01238A

27. Lippert, A. R. “Unlocking the Potential of Chemiluminescence Imaging.” ACS Cent. Sci. 2017 3, 269-271. doi:10.1021/acscentsci.7b00107 (First Reactions)

26. Lippert, A. R.*; Cao, J. “1-(Cyanomethyl)tetrahydro-1H-thiophen-1-ium Bromide.” e-EROS Encyclopedia of Reagents for Organic Synthesis 2016 1-4. doi:10.1002/047084289X.rn01962

25. Quimbar, M.E.; Krenek, K. M.; Lippert, A. R.* “A chemiluminescent platform for smartphone monitoring of H2O2 in human exhaled breath condensates.” Methods 2016, 109, 123. doi:10.1016/j.ymeth.2016.05.017

24. Cao, J.; Campbell, J.; Liu, L.; Mason, R. P.; Lippert, A. R.* “In Vivo Chemiluminescent Imaging Agents for Nitroreductase and Tissue Oxygenation.” Anal. Chem. 2016, 88, 4995. doi:10.1021/acs.analchem.6b01096

23. Cao, J.; Lopez, R.; Thacker J. M.; Moon, J. Y.; Jiang, C.; Morris, S. N. S.; Bauer, J. H.; Tao, P.; Mason, R. P.; Lippert, A. R.* “Chemiluminescent Probes for Imaging H2S in Living Animals.” Chem. Sci. 2015, 6, 1979. doi: 10.1039/C4SC03516J

22. Lin, V. S.; Lippert, A. R.*; Chang, C. J.* “Azide-Based Fluoresent Probes: Imaging Hydrogen Sulfide in Living Systems.” Methods Enzymol. 2015, 1264, 231. doi: 10.1016/bs.mie.2014.11.011

21. Lippert, A. R.*; Dickinson, B. C.; New, E. J. “Chapter 21: Imaging Mitchondrial Hydrogen Peroxide in Living Cells.” Methods Mol. Biol. 2015, 554, 63. doi: 10.1007/978-1-4939-2257-4_21

20. Bruemmer, K. J.; Merrikhihaghi, S.; Lollar, C. T.; Morris, S. N. S.; Bauer, J. H.; Lippert, A. R.* “19F Magnetic Resonance Probes for Detecting Peroxynitrite in Living Cells Using an Oxidative Decarbonylation Reaction.” Chem. Commun. 2014, 50, 12311. doi: 10.1039/C4CC04292A

19. Lippert, A. R.* “Designing Reaction-Based Fluorescent Probes for Selective Hydrogen Sulfide Detection.” J. Inorg. Biochem. 2014, 133, 136. doi: 10.1016/j.jinorgbio.2013.10.010

18. Lollar, C. T.; Krenek, K. M.; Bruemmer, K.J.; Lippert, A. R.* “Ylide Mediated Carbonyl Homologations for the Preparation of Isatin Derivatives.” Org. Biomol. Chem. 2014, 12, 406. doi: 10.1039/C3OB42024H

17. Lin, V. S.; Lippert, A. R.; Chang, C. J.* “Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production.” Proc. Natl. Acad. Sci. USA 2013, 110, 7131. doi: 10.1073/pnas.1302193110 (Highlighted in the April 22 issue of Chemical & Engineering News)

16. Wise, J. G.; Vogel, P. D.; Lippert, A. R.; Nanyakkara, A. K.; Aljowni, M. A. (Southern Methodist University) “Inhibitors of Multidrug Resistance Transporter P-Glycoprotein.” U.S. Patent Application 15,911,441, filed July 5, 2018.

15. Patel, S. K.; Lippert, A. R. (Southern Methodist University) “System and Method for a Three-Dimensional Optical Switch Display (OSD) Device.” U.S. Patent Application 62,293,128, filed October 7, 2016.

14. Terrell, J. B.; Lippert, A. R.; Raicevic, S. (LMG Innovations, LLC) “Chemiluminescent Spray and Methods Related Thereto.” U.S. Provisional Patent Application 62,331,896, filed May 19, 2016.

13. Krenek, K. M.; Lippert, A. R. (Southern Methodist University) “Composition, Device and Imaging System for Analysis Using Chemiluminescent Probes”, U.S. Patent Application 14,741,141, filed June 16, 2015.

12. Lippert, A. R.; Chang, C. J. (The Regents of The University of California, Oakland, CA) “Compositions and Methods for Imaging”, U.S. Patent 13,816,620, filed August 22, 2011, and issued August 15, 2013.

11. Lippert, A. R.; Lin, V.; Chang, C. J. (The Regents of The University of California, Oakland, CA) “Fluorescent Probes for Reactive Sulfur Species”, U.S. Patent 13,493,253, filed June 10, 2011, and issued Dec 27, 2012.

10. Michel, B. W.; Lippert, A. R.; Chang, C. J.* “A Reaction-Based Fluorescent Probe for Selective Imaging of Carbon Monoxide in Living Cells Using a Palladium- Mediated Carbonylation.” J. Am. Chem. Soc. 2012 , 124, 15668.

9. Lippert, A. R.; Van De Bittner, G. C.; Chang, C. J.* “Boronate Oxidation as a Bioorthogonal Reaction Approach for Studying the Chemistry of Hydrogen Peroxide in Living Systems.” Acc. Chem. Res. 2011 , 47, 793.

8. Lippert, A. R.; New, E. J.; Chang, C. J.* “Reaction-Based Fluorescent Probes for the Selective Imaging of Hydrogen Sulfide in Living Cells.” J. Am. Chem. Soc. 2011 , 133, 10078. (Highlighted in the October 17 issue of Chemical & Engineering News)

7. Lippert, A. R.; Keshari, K. R.; Kurhanewicz, J.; Chang, C. J.* “A Hydrogen Peroxide Responsive Hyperpolarized 13C MRI Contrast Agent.” J. Am. Chem. Soc. 2011 , 133, 3776.

6. Lippert, A. R.; Naganawa, A.; Keleshian, V. L.; Bode, J. W.* “Synthesis of Phototrappable Shapeshifting Molecules for Adaptive Guest Binding.” J. Am. Chem. Soc. 2010 , 132, 15790.

5. Lippert, A. R.; Gschneidtner, T.; Chang, C. J.* “Lanthanide-Based Luminescent Probes for Selective Time- Gated Detection of Hydrogen Peroxide in Water and Living Cells.” Chem. Commun. 2010 , 46, 7510.

4. Lippert, A. R.; Keleshian, V. L.; Bode, J. W.* “Dynamic Supramolecular Complexation by Shapeshifting Organic Molecules.” Org. Biomol. Chem. 2009 , 7, 1529.

3. Ju, L.; Lippert, A. R.; Bode, J. W.* “Stereoretentive Synthesis and Chemoselective Amide-Forming Ligations of C- Terminal Peptide alpha-Ketoacids.” J. Am. Chem. Soc. 2008 , 130, 4253.

2. Lippert, A. R.; Kaeobamrung, J.; Bode, J. W.* “Synthesis of Oligosubstituted Bullvalones: Shapeshifting Molecules Under Basic Conditions.” J. Am. Chem. Soc. 2006 , 128, 14738.

1. Khidekel, N.; Arndt, S.; Lamarre-Vincent, N.; Lippert, A.; Poulin-Kerstien, K. G.; Ramakrishnan, B.; Qasba, P. K.; Hsieh-Wilson, L. C.* “A Chemoenzymatic Approach toward Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications.” J. Am. Chem. Soc. 2003 , 125, 16162.