Dallas Morning News Originally Posted: Aug 30, 2021 The Cancer Prevention and Research Institute of Texas is gambling on scientists with big ideas and even bigger potential. Uttam Tambar knew his research could flop. “This is going to sound like a crazy idea,” he said in an email to co-worker Bruce Posner last fall about a potential grant proposal to the Cancer Prevention and Research Institute of Texas. A self-proclaimed big-picture guy, thinking unconventionally and taking risks is expected of the University of Texas Southwestern Medical Center biomedical scientist. His proposal did seem crazy, at least at first glance. He wanted to use high-throughput technology in Posner’s lab to find new molecules, called protein degraders, at a pace that’s never been done before. If the [...]
KERA Originally Post4ed: Aug. 26, 2021 LISTEN Researchers at Southern Methodist University (SMU) have discovered a way to more effectively treat cervical cancer with lower chemotherapy doses and fewer side effects. The key is a protein called TIGAR, which is found in various forms of cancer cells, including cervical cancer cells. Researchers found that if they decreased the TIGAR protein, it made the cells hypersensitive to chemotherapy treatments. In the long run, this could mean a shorter period of treatment for patients and fewer side effects to healthy cells in their bodies. Robert Harrod, a biological sciences professor at SMU who runs a lab, has seen this project evolve over a few decades. “We're finding out something new every day, putting in new pieces of [...]
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Originally Posted: Aug 23, 2021 Welcome back, Mustangs! Can't wait to see you in class!
SMU News Effective August 12, SMU is temporarily requiring masks (two or more layers covering the nose and mouth) in indoor spaces on campus, including classrooms, event and meeting spaces, and common areas in all buildings and residential halls regardless of vaccination status. Masks are not required in private spaces such as residence hall rooms for students with roommates. All events, such as Convocation and orientation, should continue as planned with masks being used indoors. This requirement is a temporary precaution during the Delta variant surge to supplement our other pandemic protocols. We will continue to monitor and review industry-specific guidance and recommendations from the federal Centers for Disease Control and Prevention and state public health authorities in order to make the best decisions for [...]
Science Advances Originally Posted: July 16, 2021 Congratulations to Richard S. Jones, SMU professor and chair of the Department of Biological Sciences. Research from his lab was published in Science Advances on July 16, 2021. For a research summary, click here. Paper Abstract from Science Advances Polycomb-group (PcG) proteins are epigenetic regulators that maintain the transcriptional repression of target genes following their initial repression by transcription factors. PcG target genes are repressed in some cells, but active in others. Therefore, a mechanism must exist by which PcG proteins distinguish between the repressed and active states and only assemble repressive chromatin environments at target genes that are repressed. Here, we present experimental evidence that the repressed state of a Drosophila PcG target gene, giant (gt), is not [...]
SMU NEWS As SMU moves into Summer Session II (July term), it’s important to maintain a healthy campus by diligently following SMU’s current COVID-19 protocols. Here are some reminders. The Mustang Strong Dashboard recording COVID-19 cases at SMU is now updated weekly on Thursdays. SMU strongly encourages everyone to receive the COVID-19 vaccination to prevent the spread and lessen the severity of the virus, if contracted. COVID-19 vaccinations are available at the Dr. Bob Smith Health Center for current and incoming students, SMU employees and their eligible spouse/dependents. Book an appointment through the health portal or by calling 214-768-2141 (option 1). After receiving the vaccine, please record your status in the voluntary vaccination reporting tool. The Health Center also provides COVID-19 testing for students and employees, but appointments are required, so call first at 214-768-2141 [...]
Dallas Morning News Originally Posted: June 29, 2021 While he was in college, James McCormick received bad news: His grandmother had developed Alzheimer’s. “When somebody gets a disease [that] you don’t know much about,” he said, “you want to research it and learn more about it.” He was used to poring through primary research articles, but later, he was surprised to recognize a protein he was already familiar with from his graduate studies at SMU called P-glycoprotein. That protein might have the ability to squeeze another harmful protein associated with Alzheimer’s out of cells. Through his readings, McCormick realized that his own skills in computer modeling could help scientists figure out how that removal process might work. Scientists believe that memory loss, confusion and other [...]
SMU News Originally Posted: June 23, 2021 Research reveals inhibiting TIGAR enhances the susceptibility of HPV+ cancer cells to chemotherapy drugs that induce oxidative stress [Yapindi et al. 2021, J Antivirals & Antiretrovirals 13(3), in press]. READ MORE
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