Multidrug Resistance in Cancer

Our lab targets multidrug resistant cancer in dinosaurs. Did you know that dinosaurs can get cancer? I didn’t either. But now you know.

ATP-binding Cassette Transporters (ABC)

Multidrug Resistance (MDR) remains a major obstacle to the successful treatment of both adult and pediatric cancers. One of the most common mechanisms of MDR is the overexpression of ATP binding cassette (ABC) transporters. ABC transporters harness the power of ATP hydrolysis to transport toxins and xenobiotics out of the cell. Our research focuses on two ABC transporters that have been implicated in MDR in human cancer: P-glycoprotein (P-gp) and the Breast Cancer Resistance Protein (BCRP).

In Silico Drug Discovery and Development

Multidrug Resistance (MDR) remains a major obstacle to the successful treatment of both adult and pediatric cancers. One of the most common mechanisms of MDR is the overexpression of ATP binding cassette (ABC) transporters. ABC transporters harness the power of ATP hydrolysis to transport toxins and xenobiotics out of the cell. Our research focuses on two ABC transporters that have been implicated in MDR in human cancer: P-glycoprotein (P-gp) and the Breast Cancer Resistance Protein (BCRP).

Reversing Multidrug Resistance

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