John Wise

Drugs behave as predicted in computer model of key protein, enabling cancer drug discovery

Wise, P-gp, P-glycoprotein, SMUDrugs important in the battle against cancer responded the way they do in real life and behaved according to predictions when tested in a computer-generated model of one of the cell’s key molecular pumps — the protein P-glycoprotein, or P-gp.

Biologists at SMU developed the computer generated model to overcome the problem of relying on only static images for P-gp’s structure, said biologist John G. Wise, lead researcher. Continue reading

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Researchers discover new drug-like compounds that may improve odds for men battling prostate cancer

P-gp, P-glycoprotein, prostate, cancer, SMU, VogelResearchers at Southern Methodist University, Dallas, have discovered three new drug-like compounds that could ultimately offer better odds of survival to prostate cancer patients.

The drug-like compounds can be modified and developed into medicines that target a protein in the human body that is responsible for chemotherapy resistance in cancers, said biochemist Pia D. Vogel. Continue reading

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The power of ManeFrame: SMU’s new supercomputer boosts research capacity

SMU now has a powerful new tool for research – one of the fastest academic supercomputers in the nation – and a new facility to house it.

With a cluster of more than 1,000 Dell servers, the system’s capacity is on par with high-performance computing (HPC) power at much larger universities and at government-owned laboratories. The U.S. Department of Defense awarded the system to SMU in August 2013. Continue reading

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Moving 3D computer model of key human protein is powerful new tool in fight against cancer

A picture is worth 1,000 words when it comes to understanding how things work, but 3D moving pictures are even better. That’s true for scientists trying to stop cancer by better understanding the proteins that make some chemotherapies unsuccessful. Now SMU biochemist John G. Wise at SMU has brought to life in a moving 3D computer model the structure of a key protein related to recurring cancers. Continue reading

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Modeling the human protein in search of cancer treatment: An SMU Researcher Q&A

SMU biologists Pia Vogel and John Wise in the SMU Department of Biological Sciences are using the computational power of the SMU high-performance supercomputer to screen millions of drug compounds.

They hope to find a compound that can be developed into a drug that re-enables chemotherapy after it fails to work against recurring cancer. Continue reading

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Aids, cancer targeted by biology researchers

Harrod%2CRobert%20lab2.jpgIn his third-floor laboratory in Dedman Life Sciences Building, biologist Robert Harrod and his team are zeroing in on a new way to inhibit the virus that causes AIDS. They already have shown that their approach, which involves the rare genetic disorder Werner syndrome, works when the disorder’s enzyme defect is introduced into cells.

Now they are trying to find practical ways to use this pathway to inhibit the AIDS virus. The beauty of this approach is that the AIDS virus will not be able to mutate in a way that can defeat this treatment, says Harrod, associate professor in the Biological Sciences Department of Dedman College.

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