wise vogel P-glycoprotein

Top Quark: New precise particle measurement improves subatomic tool for probing mysteries of universe

Physicists at Southern Methodist University, Dallas have achieved a new precise measurement of a key subatomic particle, opening the door to better understanding some of the deepest mysteries of our universe.

The researchers calculated the new measurement for a critical characteristic — mass — of the Top Quark. The new SMU value confirms recent measurements by other physicists — but adds growing uncertainty to physics’ Standard Model. Continue reading

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HuffPo: Cheating in Sports — Where Do We Go From Here?

2015-09-13-1442168688-1501438-HuffPoFairnessFinalpic-thumbSMU physiologist and biomechanics researcher Peter G. Weyand contributed a piece on cheating in sports to the U.S. online news magazine and blog the Huffington Post.

The piece addresses how modern cheating controversies in sports indicate the need for a new approach to judge fairness that encompasses a broader range of possibilities. Continue reading

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Drugs behave as predicted in computer model of key protein, enabling cancer drug discovery

Wise, P-gp, P-glycoprotein, SMUDrugs important in the battle against cancer responded the way they do in real life and behaved according to predictions when tested in a computer-generated model of one of the cell’s key molecular pumps — the protein P-glycoprotein, or P-gp.

Biologists at SMU developed the computer generated model to overcome the problem of relying on only static images for P-gp’s structure, said biologist John G. Wise, lead researcher. Continue reading

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Researchers discover new drug-like compounds that may improve odds for men battling prostate cancer

P-gp, P-glycoprotein, prostate, cancer, SMU, VogelResearchers at Southern Methodist University, Dallas, have discovered three new drug-like compounds that could ultimately offer better odds of survival to prostate cancer patients.

The drug-like compounds can be modified and developed into medicines that target a protein in the human body that is responsible for chemotherapy resistance in cancers, said biochemist Pia D. Vogel. Continue reading

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Moving 3D computer model of key human protein is powerful new tool in fight against cancer

A picture is worth 1,000 words when it comes to understanding how things work, but 3D moving pictures are even better. That’s true for scientists trying to stop cancer by better understanding the proteins that make some chemotherapies unsuccessful. Now SMU biochemist John G. Wise at SMU has brought to life in a moving 3D computer model the structure of a key protein related to recurring cancers. Continue reading

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Modeling the human protein in search of cancer treatment: An SMU Researcher Q&A

SMU biologists Pia Vogel and John Wise in the SMU Department of Biological Sciences are using the computational power of the SMU high-performance supercomputer to screen millions of drug compounds.

They hope to find a compound that can be developed into a drug that re-enables chemotherapy after it fails to work against recurring cancer. Continue reading

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